Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Invitrogen
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MA5-11527 targets Caspase 6 in IP and WB applications and shows reactivity with Human samples.
The MA5-11527 immunogen is recombinant human caspase 6 prodomain.
Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase-8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase-3 and Caspase-7, which in turn cause cell collapse.
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