Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
MA5-15281 targets ZAP70 in IHC and WB applications and shows reactivity with Human samples.
The MA5-15281 immunogen is purified recombinant fragment of human ZAP70 expressed in E. Coli.
MA5-15281 detects ZAP70 which has a predicted molecular weight of approximately 70kDa.
ZAP-70 is a cytosolic protein tyrosine kinase that is a member of the Syk family of proteins. ZAP-70 is expressed exclusively in T-cells and natural killer cells and is required for T-cell receptor activation. Upon T cell antigen receptor (TCR) engagement, ZAP70 is phosphorylated on tyrosines 292, 315 and 319 in the interdomain B, located between the SH2 and kinase domains. Phosphorylation of both tyrosines 315 (a Vav binding site) and 319 (a Lck binding site) enhances ZAP70 function in mediating lymphocyte signaling, while tyrosine 292 terminates the transient activation of ZAP70 and attentuates lymphocyte signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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