Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
OPA1-03898 detects Retinoblastoma from human samples phosphorylated at threonine 821. OPA1-03898 is expected to react with mouse and rat samples but has not been tested.
OPA1-03898 has been successfully used in Western blot procedures.
OPA1-03898 immunizing phosphopeptide is derived from the region of Rb that contains threonine 821. This sequence is 100% conserved in mouse and rat Retinoblastoma.
Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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