ImmunoCAP Total IgE
Quantify Total Concentration of IgE

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ImmunoCAP™ Total IgE measures the total amount of circulating IgE in human serum or plasma samples.1 IgE antibodies can appear as a result of sensitization to allergens. In many patients suffering from asthma, rhinitis, or atopic dermatitis due to allergy, the concentration of total IgE may be elevated.1,3-5

ImmunoCAP Total IgE is a fully quantitative test that provides accurate levels of circulating IgE within a wide measuring range between 2 to 5000 kU/L.1 For patients with low serum IgE levels, ImmunoCAP Total IgE Low Range offers quantitative measurement between 0.1-100 kU/L.2


Clinical utility

  • Total serum IgE levels vary with atopic status6 and are an aid for healthcare professionals in the clinical diagnosis of IgE-mediated allergic disorders.1,2
  • For patients with suspected occupational allergy without an atopic background, elevated serum IgE levels provide an indication of sensitization caused by high allergen exposure.7,8
  • Parasite intestinal infections have been shown to induce the production of IgE, resulting in elevated serum IgE levels.9
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  1. Directions for use. ImmunoCAP Total IgE.
  2. Directions for use. ImmunoCAP Total IgE Low Range.
  3. Cakanlar, F.N., E. Ceylan, and A. Kanbay, Relationship between serum total ige specific ige and serum total eosinophil counts in asthma bronchiale patients. World Allergy Organization Journal, 2015. 8(Suppl 1): p. A25.
  4. Poleshuck, R.T.F., et al., Levels of total serum IgE and specific IgE sensitization profile in patients with atopic dermatitis. World Allergy Organization Journal, 2015. 8(1): p. A142-A142.
  5. Poleshuck, Rafael Teixeira Figueredo et al. “Levels of total serum IgE and specific IgE sensitization profile in patients with atopic dermatitis” World Allergy Organization Journal, Volume 8, A142
  6. Wayne T. R. and Hales B. J. “Immune Responses to Inhalant Allergens”; WAO Journal 2008;89-95
  7. Hollund, B.E., et al., Occupational exposure to hairdressing chemicals and immunoglobulin E synthesis. Scand J Work Environ Health, 2002. 28(4): p. 264-9.
  8. Hossain;, M.A. and L.N. Islam, Effect of Occupational Exposure on Allergic Diseases and Relationship with Serum IgE Levels in the Tannery Workers in Bangladesh. 2016.
  9. De Farias Sales, V.S., et al., Serum total IgE, ascaris lumbricoides specific IgE and eosinophils in parasites-infected children in a tropical area. The World Allergy Organization Journal, 2015. 8(Suppl 1): p. A223-A223.