Shop All Hepatocytes
Cryopreserved Human Kupffer Cells (Gibco™)
Cryopreserved Human Kupffer Cells are isolated from adult human livers. Each vial contains a minimum of one million viable cells. These easy-to-use cells provide a convenient way to produce hepatocyte and Kupffer cell co-cultures for the study of various hepatic functions.These cells typically have high viabilities and in vivo-like expression levels.
• Viability routinely >90%
• Purity routinely >90%
• Respond to activation with lipopolysaccharides (LPS)
• Minimum 1 million viable cells per vial
• Protocols for hepatocyte co-culture available
Kupffer Cells Provide for Improved Physiological Modeling
Growing evidence shows that under both normal and pathological conditions, many hepatocyte functions are regulated by substances released from neighboring non-parenchymal cells (NPC). These cells, particularly Kupffer cells, play an important role in the modulation of xenobiotic metabolism in the liver. Kupffer cells secrete potent mediators of the inflammatory response that controls liver inflammation. These cytokine mediators control hepatocyte metabolic rates through direct interactions with phase I and phase II enzymes. Kupffer cell and hepatocyte co-cultures can self-assemble within 72 hours of treatment with pro-inflammatory cytokines or LPS, and can function by effectively modulating P450 expression, thus giving a more physiologically relevant result. Studies indicate that co-culture of hepatocytes with NPCs better represent both normal liver physiology as well as disease states.
• Viability routinely >90%
• Purity routinely >90%
• Respond to activation with lipopolysaccharides (LPS)
• Minimum 1 million viable cells per vial
• Protocols for hepatocyte co-culture available
Kupffer Cells Provide for Improved Physiological Modeling
Growing evidence shows that under both normal and pathological conditions, many hepatocyte functions are regulated by substances released from neighboring non-parenchymal cells (NPC). These cells, particularly Kupffer cells, play an important role in the modulation of xenobiotic metabolism in the liver. Kupffer cells secrete potent mediators of the inflammatory response that controls liver inflammation. These cytokine mediators control hepatocyte metabolic rates through direct interactions with phase I and phase II enzymes. Kupffer cell and hepatocyte co-cultures can self-assemble within 72 hours of treatment with pro-inflammatory cytokines or LPS, and can function by effectively modulating P450 expression, thus giving a more physiologically relevant result. Studies indicate that co-culture of hepatocytes with NPCs better represent both normal liver physiology as well as disease states.
Mouse (CD-1) Cryopreserved Hepatocytes, Plateable Male (Gibco™)
These plateable cryopreserved male mouse (CD-1) hepatocytes have been characterized for general Phase I and Phase II drug metabolizing enzyme activities.
Cells per vial: 4-8 million
Get the Results You Need with GIBCO® Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro⁄in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure that you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
• Phase I and II enzyme activities
• Proper morphology
• Viabilities generally >75%
• Attachment efficiency
• Monolayer formation and integrity
For research use only. Not intended for human or animal therapeutic or diagnostic use.
Related Links:
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes ,
Note:
These products require shipment in LN2 vapor dewars therefore additional fees may apply.
Cells per vial: 4-8 million
Get the Results You Need with GIBCO® Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro⁄in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure that you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
• Phase I and II enzyme activities
• Proper morphology
• Viabilities generally >75%
• Attachment efficiency
• Monolayer formation and integrity
For research use only. Not intended for human or animal therapeutic or diagnostic use.
Related Links:
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes ,
Note:
These products require shipment in LN2 vapor dewars therefore additional fees may apply.
Mouse (CD-1) Cryopreserved Hepatocytes, Plateable Female (Gibco™)
These plateable cryopreserved female mouse (CD-1) hepatocytes have been characterized for general Phase I and Phase II drug metabolizing enzyme activities.
Cells per vial: 4-8 million
Get the Results You Need with GIBCO Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro⁄in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
• Phase I and II enzyme activities
• Proper morphology
• Viabilities generally >75%
• Attachment efficiency
• Monolayer formation and integrity
For research use only. Not intended for human or animal therapeutic or diagnostic use.
Related Links:
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes ,
Note:
These products require shipment in LN2 vapor dewars therefore additional fees may apply.
Cells per vial: 4-8 million
Get the Results You Need with GIBCO Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro⁄in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
• Phase I and II enzyme activities
• Proper morphology
• Viabilities generally >75%
• Attachment efficiency
• Monolayer formation and integrity
For research use only. Not intended for human or animal therapeutic or diagnostic use.
Related Links:
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes ,
Note:
These products require shipment in LN2 vapor dewars therefore additional fees may apply.
Mouse (CD-1) Cryopreserved Hepatocytes, Male (Gibco™)
These cryopreserved male mouse (CD-1) hepatocytes have been characterized for general Phase I and Phase II drug metabolizing enzyme activities.
Cells per vial: 4-8 million
Get the Results You Need with GIBCO Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro⁄in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
• Phase I and II enzyme activities
• Proper morphology
• Viabilities generally >75%
For research use only. Not intended for human or animal therapeutic or diagnostic use.
Related Links:
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes ,
Note:
These products require shipment in LN2 vapor dewars therefore additional fees may apply.
Cells per vial: 4-8 million
Get the Results You Need with GIBCO Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro⁄in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
• Phase I and II enzyme activities
• Proper morphology
• Viabilities generally >75%
For research use only. Not intended for human or animal therapeutic or diagnostic use.
Related Links:
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes ,
Note:
These products require shipment in LN2 vapor dewars therefore additional fees may apply.
Mouse (CD-1) Cryopreserved Hepatocytes, Female (Gibco™)
These cryopreserved female mouse (CD-1) hepatocytes have been characterized for general Phase I and Phase II drug metabolizing enzyme activities.
Cells per vial: 4-8 million
Get the Results You Need with GIBCO Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro⁄in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
• Phase I and II enzyme activities
• Proper morphology
• Viabilities generally >75%
For research use only. Not intended for human or animal therapeutic or diagnostic use.
Related Links:
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes ,
Note:
These products require shipment in LN2 vapor dewars therefore additional fees may apply.
Cells per vial: 4-8 million
Get the Results You Need with GIBCO Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro⁄in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
• Phase I and II enzyme activities
• Proper morphology
• Viabilities generally >75%
For research use only. Not intended for human or animal therapeutic or diagnostic use.
Related Links:
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes ,
Note:
These products require shipment in LN2 vapor dewars therefore additional fees may apply.
Human Plateable Hepatocytes, Transporter Qualified (Gibco™)
Plateable cryopreserved human hepatocytes assessed for transporter function using uptake transporter assays at both 4°C and 37°C.
Cells per vial: 4-8 million
Hepatocyte cultures were incubated with radiolabeled taurocholate, digoxin, and estradiol 17β glucuronide (E2-17G), substrates of the uptake and efflux transporters NTCP and BSEP, OCT1 and MDR1, and OATPs and MRP2, respectively. Accumulation rates and biliary excretion index (BEI%) were calculated.
Get the Results You Need with GIBCO Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro⁄in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
• Phase I and II enzyme activities
• Proper morphology
• Viabilities generally >75%
• Attachment efficiency
• Monolayer formation and integrity
For research use only. Not intended for human or animal therapeutic or diagnostic use.
Related Links:
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes ,
Note:
These products require shipment in LN2 vapor dewars therefore additional fees may apply.
Cells per vial: 4-8 million
Hepatocyte cultures were incubated with radiolabeled taurocholate, digoxin, and estradiol 17β glucuronide (E2-17G), substrates of the uptake and efflux transporters NTCP and BSEP, OCT1 and MDR1, and OATPs and MRP2, respectively. Accumulation rates and biliary excretion index (BEI%) were calculated.
Get the Results You Need with GIBCO Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro⁄in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
• Phase I and II enzyme activities
• Proper morphology
• Viabilities generally >75%
• Attachment efficiency
• Monolayer formation and integrity
For research use only. Not intended for human or animal therapeutic or diagnostic use.
Related Links:
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes ,
Note:
These products require shipment in LN2 vapor dewars therefore additional fees may apply.
Fish (rainbow trout) Cryopreserved Hepatocytes, Male (Gibco™)
These cryopreserved male rainbow trout (Oncorhynchus mykiss) hepatocytes have been characterized for general Phase I and Phase II drug metabolizing enzyme activities.
Cells per vial: 4-8 million
Get the Results You Need with GIBCO Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro⁄in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
• Phase I and II enzyme activities
• Proper morphology
• Viabilities generally >75%
For research use only. Not intended for human or animal therapeutic or diagnostic use.
Related Links:
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes ,
Note:
These products require shipment in LN2 vapor dewars therefore additional fees may apply.
Cells per vial: 4-8 million
Get the Results You Need with GIBCO Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro⁄in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
• Phase I and II enzyme activities
• Proper morphology
• Viabilities generally >75%
For research use only. Not intended for human or animal therapeutic or diagnostic use.
Related Links:
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes ,
Note:
These products require shipment in LN2 vapor dewars therefore additional fees may apply.
Cryopreserved Rat Kupffer Cells
These cryopreserved purified Kupffer cells are isolated from adult male Sprague-Dawley rats. Each vial contains a minimum of one million cells.
Easy to use cryopreserved Kupffer cells provide a convenient way to produce custom cell ratios for hepatic co-culture.
Each lot of Cryopreserved Rat Kupffer Cells is tested for:
• Purity
• Response to activation with LPS
• Adherence
• Minimum 1 million cells per vial
Kupffer Cells for Improved Physiological Modeling
Growing evidence shows that under both normal and pathological conditions, many hepatocyte functions are regulated by substances released from neighboring non-parenchymal cells (NPC). These cells, particularly Kupffer cells, play an important role in the modulation of xenobiotic metabolism in the liver. Kupffer cells secrete potent mediators of the inflammatory response that controls liver inflammation. These cytokine mediators control hepatocyte metabolic rates through direct interactions with phase I and phase II enzymes. Kupffer cell and hepatocyte co-cultures can self-assemble within 72 hours of treatment with pro-inflammatory cytokines or LPS, and can function by effectively modulating P450 expression, thus giving a more physiologically relevant result. Studies indicate that co-culture of hepatocytes with NPCs would better represent both normal liver physiology as well as disease states.
For Research Use Only. Not intended for any animal or human therapeutic or diagnostic use.,
Note:
These products require shipment in LN2 vapor dewars therefore additional fees may apply.
Easy to use cryopreserved Kupffer cells provide a convenient way to produce custom cell ratios for hepatic co-culture.
Each lot of Cryopreserved Rat Kupffer Cells is tested for:
• Purity
• Response to activation with LPS
• Adherence
• Minimum 1 million cells per vial
Kupffer Cells for Improved Physiological Modeling
Growing evidence shows that under both normal and pathological conditions, many hepatocyte functions are regulated by substances released from neighboring non-parenchymal cells (NPC). These cells, particularly Kupffer cells, play an important role in the modulation of xenobiotic metabolism in the liver. Kupffer cells secrete potent mediators of the inflammatory response that controls liver inflammation. These cytokine mediators control hepatocyte metabolic rates through direct interactions with phase I and phase II enzymes. Kupffer cell and hepatocyte co-cultures can self-assemble within 72 hours of treatment with pro-inflammatory cytokines or LPS, and can function by effectively modulating P450 expression, thus giving a more physiologically relevant result. Studies indicate that co-culture of hepatocytes with NPCs would better represent both normal liver physiology as well as disease states.
For Research Use Only. Not intended for any animal or human therapeutic or diagnostic use.,
Note:
These products require shipment in LN2 vapor dewars therefore additional fees may apply.
Rat (Sprague-Dawley) Cryopreserved Hepatocytes, Plateable Male (Gibco™)
These plateable cryopreserved male rat (Sprague-Dawley) hepatocytes have been characterized for general Phase I and Phase II drug metabolizing enzyme activities.
Cells per vial: 4-8 million
Get the Results You Need with GIBCO Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro⁄in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
• Phase I and II enzyme activities
• Proper morphology
• Viabilities generally >75%
• Attachment efficiency
• Monolayer formation and integrity
For research use only. Not intended for human or animal therapeutic or diagnostic use.
Related Links:
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes ,
Note:
These products require shipment in LN2 vapor dewars therefore additional fees may apply.
Cells per vial: 4-8 million
Get the Results You Need with GIBCO Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro⁄in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
• Phase I and II enzyme activities
• Proper morphology
• Viabilities generally >75%
• Attachment efficiency
• Monolayer formation and integrity
For research use only. Not intended for human or animal therapeutic or diagnostic use.
Related Links:
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes ,
Note:
These products require shipment in LN2 vapor dewars therefore additional fees may apply.
Human Suspension Hepatocytes, Metabolism Qualified, Male, (9-12 x 106 cells) (Gibco™)
These cryopreserved human male hepatocytes are suitable for use in suspension metabolism applications.
Cells per vial: 9-12 million
The commonly tested Phase I (P450) and Phase II (UGT, SULT) drug metabolizing enzymes were analyzed for metabolic activity in each lot. Metabolite formation was measured by standard biochemical assays using LC⁄MS⁄MS or HPLC.
Get the Results You Need with GIBCO Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro⁄in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
• Phase I and II enzyme activities
• Proper morphology
• Viabilities generally >75%
For research use only. Not intended for human or animal therapeutic or diagnostic use.
Related Links:
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes ,
Note:
These products require shipment in LN2 vapor dewars therefore additional fees may apply.
Cells per vial: 9-12 million
The commonly tested Phase I (P450) and Phase II (UGT, SULT) drug metabolizing enzymes were analyzed for metabolic activity in each lot. Metabolite formation was measured by standard biochemical assays using LC⁄MS⁄MS or HPLC.
Get the Results You Need with GIBCO Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro⁄in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
• Phase I and II enzyme activities
• Proper morphology
• Viabilities generally >75%
For research use only. Not intended for human or animal therapeutic or diagnostic use.
Related Links:
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes ,
Note:
These products require shipment in LN2 vapor dewars therefore additional fees may apply.
Monkey (cynomolgus) Cryopreserved Hepatocytes, Male (Gibco™)
These cryopreserved male Cynomolgus Monkey hepatocytes have been characterized for general Phase I and Phase II drug metabolizing enzyme activities.
Cells per vial: 4-8 million
Get the Results You Need with GIBCO Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro⁄in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
• Phase I and II enzyme activities
• Proper morphology
• Viabilities generally >75%
For research use only. Not intended for human or animal therapeutic or diagnostic use.
Related Links:
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes ,
Note:
These products require shipment in LN2 vapor dewars therefore additional fees may apply.
Cells per vial: 4-8 million
Get the Results You Need with GIBCO Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro⁄in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
• Phase I and II enzyme activities
• Proper morphology
• Viabilities generally >75%
For research use only. Not intended for human or animal therapeutic or diagnostic use.
Related Links:
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes ,
Note:
These products require shipment in LN2 vapor dewars therefore additional fees may apply.
Human Plateable Hepatocytes, 5-Donor (Gibco™)
These "5-Donor" Human Plateable Hepatocytes are a pooled population of primary hepatocytes produced by combining cells from 5 individual donors in a single vial. Pooling donors helps to minimize lot-to-lot variation and improves predictability of drug metabolism studies and other biological assays.
• Pure, highly viable, plateable hepatocytes
• Lot-specific characterization data
• Thawing and plating process compatible with existing protocols
Consistent cell attachment
These high-quality plateable primary hepatocytes have in vivo-like enzyme expression levels and proper cell morphology, with such in vitro vs. in vivo correlations helping enable more sound decisions regarding the fate of compounds being tested.
5 donors in a single vial
The cells are provided in a cryopreserved format similar to single donor plateable hepatocytes and have been shown to have approximately equal representation of each donor when plated.
Verified activity
Every lot of pooled plateable hepatocytes is tested for Phase I enzyme activity, cell viability, plating efficiency, and morphology.
• Pure, highly viable, plateable hepatocytes
• Lot-specific characterization data
• Thawing and plating process compatible with existing protocols
Consistent cell attachment
These high-quality plateable primary hepatocytes have in vivo-like enzyme expression levels and proper cell morphology, with such in vitro vs. in vivo correlations helping enable more sound decisions regarding the fate of compounds being tested.
5 donors in a single vial
The cells are provided in a cryopreserved format similar to single donor plateable hepatocytes and have been shown to have approximately equal representation of each donor when plated.
Verified activity
Every lot of pooled plateable hepatocytes is tested for Phase I enzyme activity, cell viability, plating efficiency, and morphology.
Human Plateable Hepatocytes, Uptake Qualified (Gibco™)
Cryopreserved human hepatocytes for use in transporter-mediated uptake applications.
Cells per vial: 4-8 million
Prototypical hepatic uptake transporter substrates taurocholate and estradiol-17β-glucuronide have been assessed to qualify the transport function of hepatic NTCP (SLC10A1) and OATP1B14/3 (SLCO1B1/3), respectively. The transport of each substrate (radiolabeled) was monitored by scintillation analysis and active transport values (37°C - 4°C) determined by linear regression.
Get the Results You Need with GIBCO® Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro/in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
• Phase I and II enzyme activities
• Proper morphology
• Viabilities generally >75%
• Attachment efficiency
• Monolayer formation and integrity
For research use only. Not intended for human or animal therapeutic or diagnostic use.
Related Link
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes
Cells per vial: 4-8 million
Prototypical hepatic uptake transporter substrates taurocholate and estradiol-17β-glucuronide have been assessed to qualify the transport function of hepatic NTCP (SLC10A1) and OATP1B14/3 (SLCO1B1/3), respectively. The transport of each substrate (radiolabeled) was monitored by scintillation analysis and active transport values (37°C - 4°C) determined by linear regression.
Get the Results You Need with GIBCO® Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro/in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
• Phase I and II enzyme activities
• Proper morphology
• Viabilities generally >75%
• Attachment efficiency
• Monolayer formation and integrity
For research use only. Not intended for human or animal therapeutic or diagnostic use.
Related Link
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes
Monkey (cynomolgus) Cryopreserved Hepatocytes, Plateable Male (Gibco™)
These plateable cryopreserved male Cynomolgus Monkey hepatocytes have been characterized for general Phase I and Phase II drug metabolizing enzyme activities.
Cells per vial: 4-8 million
Get the Results You Need with GIBCO Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro⁄in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
• Phase I and II enzyme activities
• Proper morphology
• Viabilities generally >75%
• Attachment efficiency
• Monolayer formation and integrity
For research use only. Not intended for human or animal therapeutic or diagnostic use.
Related Links:
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes ,
Note:
These products require shipment in LN2 vapor dewars therefore additional fees may apply.
Cells per vial: 4-8 million
Get the Results You Need with GIBCO Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro⁄in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
• Phase I and II enzyme activities
• Proper morphology
• Viabilities generally >75%
• Attachment efficiency
• Monolayer formation and integrity
For research use only. Not intended for human or animal therapeutic or diagnostic use.
Related Links:
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes ,
Note:
These products require shipment in LN2 vapor dewars therefore additional fees may apply.
Human Plateable Hepatocytes, Induction Qualified (Gibco™)
These plateable cryopreserved human hepatocytes are inducible and suitable for use in experiments monitoring in vitro enzyme induction.
Cells per vial: 4-8 million
The potentials of known clinically relevant enzyme inducers represented by 3-methylcholanthrene (3-MC, a prototypical CYP1A enzyme inducer, 3 µM), phenobarbital (PB, a prototypical CYP2B inducer, 1000 µM) and rifampicin (RIF, a prototypical CYP3A enzyme inducer, 10 µM) have been assessed to verify that each lot is inducible.
Get the Results You Need with GIBCO Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro/in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
• Phase I and II enzyme activities
• Proper morphology
• Viabilities generally >75%
• Attachment efficiency
• Monolayer formation and integrity
For research use only. Not intended for human or animal therapeutic or diagnostic use.
Related Links:
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes
Cells per vial: 4-8 million
The potentials of known clinically relevant enzyme inducers represented by 3-methylcholanthrene (3-MC, a prototypical CYP1A enzyme inducer, 3 µM), phenobarbital (PB, a prototypical CYP2B inducer, 1000 µM) and rifampicin (RIF, a prototypical CYP3A enzyme inducer, 10 µM) have been assessed to verify that each lot is inducible.
Get the Results You Need with GIBCO Hepatocytes
High quality hepatocytes, with high viabilities, in vivo-like enzyme expression levels, and proper cell morphology increase the ability to draw in vitro/in vivo correlations and make sound decisions regarding a compound's fate. Experienced technicians and proprietary isolation techniques combined with stringent release specifications ensure you receive the highest quality cryopreserved hepatocytes.
Each lot is tested for:
• Phase I and II enzyme activities
• Proper morphology
• Viabilities generally >75%
• Attachment efficiency
• Monolayer formation and integrity
For research use only. Not intended for human or animal therapeutic or diagnostic use.
Related Links:
Learn more about our cryopreserved hepatocytes
Learn about our full line of hepatocytes
