Protein Modification Reagents

Protein Modification Reagents

Protein modification reagents are used to modify the amino acid side chains of proteins to alter their native charges, block or expose reactive binding sites, inactivate functional groups, and change functional groups to create targets for crosslinking and labeling.
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Crosslinker Type

Labeling Method

Molecular Weight (g/mol)

Product Line

DSSO (disuccinimidyl sulfoxide) Thermo Scientific™

DSSO (disuccinimidyl sulfoxide) is an MS-cleavable and membrane-permeable crosslinker that contains an amine-reactive N-hydroxysuccinimide (NHS) ester at each end of a 7-carbon spacer arm. It facilitates analysis of protein structure and complex interactions using mass spectrometry.

Pierce™ DTT (Dithiothreitol), No-Weigh™ Format Thermo Scientific™

Thermo Scientific Pierce DTT (Dithiothreitol) is offered as 7.7 mg x 48-tube microplates for convenient preparation of 100 µL of 0.5M stocks for addition to protein samples for effective reduction of disulfide bonds.

Chymotrypsinogen A, from bovine pancreas Thermo Scientific™

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

Pepsin, porcine stomach Thermo Scientific™

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

Papain, Carica Papaya Latex Thermo Scientific™

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

Elastase, porcine pancreas aqueous suspension Thermo Scientific™

This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

Thiol and Sulfide Quantitation Kit Invitrogen™

The Thiol and Sulfide Quantitation Kit provides an ultrasensitive colorimetric assay for quantitating both protein and nonprotein thiols (also called sulfhydryls or mercaptans). In this assay, thiols or inorganic sulfides reduce a disulfide-inhibited derivative of papain, stoichiometrically...

Staphylococcus aureus V-8 Protease Thermo Scientific™

Thermo Scientific Staphylococcus aureus V-8 Protease also known as endoproteinase Glu-C, has two pH optima, one at pH 4.0 and the other at pH 7.8, and is specific for cleavage at the carboxy terminus of glutamic acid and aspartic acid residues.

Pierce™ DTT (Dithiothreitol) Thermo Scientific™

Dithiothreitol is a popular reducing agent for many protein research applications, including reducing polyacrylamide electrophoresis (SDS-PAGE). Related Products Bond-Breaker™ TCEP Solution, Neutral pH

Trypsin, TPCK Treated Thermo Scientific™

Thermo Scientific Pierce TPCK Trypsin is a serine endoprotease that is applicable to amino acid analysis and protein sequencing, mapping and structural studies; the immobilized form allows sample separation after treatment.

Immobilized Papain (Agarose Resin) Thermo Scientific™

Thermo Scientific Pierce Immobilized Papain consists of a cysteine-endopeptidase (papain) that has been immobilized onto beaded agarose resin to enable generation and purification of Fab fragments from antibodies.

Pierce™ SAT(PEG)4 (PEGylated N-succinimidyl S-acetylthioacetate) Thermo Scientific™

Thermo Scientific Pierce SAT(PEG)4 is a long-arm (18.2 angstroms), pegylated form of SATA, a sulfhydryl-addition reagent for covalent modification of primary amines to facilitate controlled, heterobifunctional crosslinking.

Pierce™ SATP (N-succinimidyl-S-acetylthiopropionate) Thermo Scientific™

Thermo Scientific Pierce SATP is a long-chain (4.1 angstrom spacer arm) reagent for covalent modification of primary amines and addition of a protected yet exposable sulfhydryl group, enabling heterobifunctional crosslinking strategies.

MA(PEG)24 Methyl-PEG-Amine Compound Thermo Scientific™

Thermo Scientific Pierce MA(PEG)24 is a methyl- and amine-terminated polyethylene glycol reagent that is useful for a variety of surface-modification and molecule-pegylation applications. Features of MA(PEG)24: • Fully characterized PEGylation reagent with defined PEG chain length; discrete...

CL(PEG)12 Carboxy-PEG-Lipoamide Compound Thermo Scientific™

Thermo Scientific Pierce CL(PEG)12, or carboxy-PEG12-lipoamide, is a carboxyl- and bidentate thiol-terminated compound that contains a 4-unit polyethylene glycol (PEG) spacer and is used to modify quantum dots, and silver or gold surfaces and particles.
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