Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Peptides are versatile molecules with a broad range of applications that continue to expand as research and technology advance. Their exceptional properties, including high specificity, biocompatibility, and ease of synthesis, make them invaluable in therapeutics, diagnostics, research, cosmetics, agriculture, nutraceuticals, and biomaterials. Due to their versatility, there has been an increase in the research and synthesis of peptides.
The synthesis of peptides can be performed using several methodologies: with the two most common being solid-phase peptide synthesis (SPPS) and liquid-phase peptide synthesis (LPPS), also known as solution phase synthesis (SPS). A key part of the synthesis, and purification of synthetic peptides, is the need for high purity chemicals.
Whether you are working in the research and development of new synthetic peptides or the production of well-known peptides, we offer the following products in both catalog and custom options (if you require specific blends or specification for your investigations):
Solvents are critical in peptide synthesis, serving as the medium in which reactions occur and impacting both the efficiency and purity of the synthesis process. Common solvents include dimethylformamide (DMF), N-methyl-2-pyrrolidone (NMP), and dichloromethane (DCM). And more recently, there is more interest to find alternative, greener solvents to support peptide synthesis.
DMF and NMP are particularly favored for their ability to dissolve a wide range of reagents and for their high polarity, which facilitates peptide bond formation. DCM is often used in solid-phase peptide synthesis (SPPS) for its excellent swelling properties with resins.
If you are interested in alternative solvent options (or blends of solvents), such as dimethyl sulfoxide (DMSO), anisole, propyl acetate, then why not reach out to learn more about our custom and bulk chemicals program.
Whether you are currently using DMF as the main solvent or you’re investigating greener alternatives (including mixtures of solvents), we have you covered.
We offer both catalog and “custom and bulk” options, in a variety of grades to support both the synthesis cycle and the purification step.
Do you need large quantities of solvents? Would you like blends/mixtures of solvents for your peptide synthesis?
Our custom and bulk option enables customers to purchase premade blends that cater to their specific needs and requirements.
Coupling, protection, and deprotection reagents play crucial roles in helping ensure the correct sequence and structure of the peptide chain.
Coupling reagents, such as EDC, facilitate the formation of peptide bonds between amino acids. Racemisation inhibitors, such as HATU and HBTU, facilitate coupling while also helping prevent loss of stereochemistry during the reaction.
N-Protection reagents, like Fmoc, Boc and Cbz, safeguard reactive functional groups on amino acids from undesired side reactions during the synthesis process.
Deprotection reagents, such as piperidine for Fmoc removal and TFA (trifluoroacetic acid) for Boc removal, are used to selectively remove these protective groups at appropriate stages, allowing the controlled and sequential building of the peptide chain.
These reagents collectively contribute to the precision and efficiency of peptide synthesis.
Amino acids are the fundamental building blocks of peptides and proteins, and their selection and handling are pivotal in peptide synthesis. Each amino acid consists of an amino group, a carboxyl group, and a unique side chain, which defines its properties and function within the peptide.
In peptide synthesis, amino acids are often used in their protected forms, such as Fmoc- or Boc-protected derivatives, to prevent side reactions during the sequential addition of each residue. The stereochemistry of amino acids, typically in the L-configuration, is crucial for the proper folding and biological activity of the synthesized peptide.
Additionally, the purity and reactivity of amino acids can significantly impact the efficiency and success of the synthesis process, making their careful selection and preparation essential for achieving high-quality peptides.
Within our portfolio, we offer high purity amino acids that can be used for peptide synthesis.
We aim to support efficient, reliable, and high-quality peptide synthesis for various applications in research and industry, with our catalog products and custom and bulk service.
For Research Use Only. Not for use in diagnostic procedures.