Maps 3 Software for correlative and automated microscopy

Correlative microscopy software supporting automated, multimodal analysis

Complex microscopy workflows often require researchers to move between instruments, imaging modalities, and scales while maintaining the context needed to interpret results. Thermo Scientific Maps 3 Software connects automated imaging, correlative microscopy, and multimodal data in a single platform for SEM, FIB-SEM, and TEM systems.

 

Maps 3 Software helps researchers move from sample overviews to nanoscale detail while preserving spatial context across imaging and analysis. Images, annotations, measurements, and analytical results remain connected within a single project as samples progress through preparation, screening, high-resolution imaging, elemental analysis, and other complementary techniques.

 

By connecting acquisition and multimodal data, Maps 3 Software helps researchers correlate results across imaging platforms, continue analysis away from the microscope, and build a more complete understanding of their samples.

Maps 3 Software is a unified platform for streamlined microscopy and analysis that combines multimodal imaging and correlative microscopy through connected projects and intelligent workflows.

Why choose Maps 3 Software?

Researchers and engineers use Maps 3 Software to:

  • Connect instruments, data, and workflows in one platform
  • Move from sample overviews to nanoscale detail while preserving spatial context
  • Streamline imaging workflows across microscopy platforms
  • Correlate multimodal images and analytical data across instruments
  • Automate image acquisition and streamline routine microscopy tasks
  • Improve consistency and reproducibility across users and labs
  • Collaborate without tying up valuable microscope time
  • Build and extend workflows as their research needs evolve

Core capabilities of Maps 3 Software

Automated image acquisition

Automate large-area, high-resolution image acquisition across single or multiple samples. Queue imaging sessions and run unattended acquisitions to reduce repetitive microscope operation and make more microscope time available for other work.

Multi-scale navigation

Navigate from whole-sample overviews to nanoscale details while preserving spatial context. Organize multiple magnifications within a single project so observations at different scales remain connected.

Multimodal data correlation

Correlate data from multiple instruments, imaging modalities, and analytical techniques within a single interactive project. This allows you to interpret complementary data from initial screening through advanced characterization without separating results from their location on the sample.

Offline collaboration

Review projects, annotate images, perform measurements, and share observations from your desktop without tying up valuable microscope time. Teams can continue reviewing and analyzing results while new data is acquired, supporting collaboration and project handoffs across users, laboratories, and locations.


Maps Discover for adaptive microscopy

Maps Discover is an adaptive, closed-loop microscopy extension for Maps 3 Software that is leveraged when the next imaging or analytical step depends on what is found during the current data acquisition. It analyzes incoming data in real time and automatically determines the next imaging, measurement, or analytical step based on user-defined criteria.

 

Researchers can combine real-time analysis with automated acquisition and extend existing Maps Software workflows using Python libraries, computer vision algorithms, or their own AI models. This approach helps reduce repetitive manual tasks and apply user-defined acquisition logic as new data is collected.

Connect analysis and acquisition with Maps Discover

A single script can combine analysis, annotation, reporting, and acquisition logic, offering closed-loop feedback to acquisition.


Creating adaptive microscopy workflows with Maps Discover Studio

Creating adaptive microscopy automation can require custom scripting. Maps Discover Studio, part of the optional Maps Discover extension for Maps 3 Software, offers a browser-based environment for creating, testing, and deploying adaptive microscopy workflows.

 

Marie, the AI-assisted script helper, generates deployable MapsBridge Python code from natural-language descriptions. Researchers can review the generated code, test it using sample microscope images, refine it, and deploy it to Maps Discover. This supports custom image analysis, computer vision workflows, and integration of user-developed AI models without requiring every line of code to be written from scratch.

Build adaptive microscopy workflows with Maps Discover Studio

Create, test, and deploy custom microscopy workflows in a browser-based environment. Marie, the AI-assisted script helper, transforms natural-language prompts into deployable MapsBridge Python code for automation and image analysis.


Maps 3 Software for materials science

Understanding material performance often requires more than a single image or analytical technique. Maps 3 Software helps materials scientists correlate complementary data from multiple instruments and imaging modalities to reveal relationships between composition, microstructure, and performance.

 

Researchers can capture large-area mosaics, identify regions of interest, and combine SEM, FIB-SEM, TEM, Raman, EDS, and other imaging data within a single interactive project. These capabilities support failure analysis, battery materials characterization, metal and alloy research, composite and geological sample analysis, additive manufacturing, and advanced ceramics research while preserving spatial context across imaging and analysis.

Automate large-area SEM imaging

Acquire large mosaic images automatically, navigate from overview to high-resolution detail, and offload routine SEM imaging tasks for unattended operation. Maps 3 Software helps researchers capture comprehensive datasets while reducing repetitive microscope operation.

Key capabilities for materials science

  • Automated large-area and multi-sample acquisition
  • Multi-instrument and multimodal correlation
  • Targeted high-resolution imaging and FIB workflows
  • Quantitative measurements and annotations
  • Connected project management and collaboration
  • Extensible workflows with Python and AI-ready analysis

 

More information

Multi-instrument data correlation with Maps 3 Software

This visualization of a geologic sample combines data from SEM, SEM-EDS, and a standalone Raman microscope. Maps 3 Software offers guided import and correlation, helping researchers align and interpret complementary data within a single environment.


Maps 3 Software for biological and 3D imaging

Understanding biological systems requires the connection of structures across multiple scales and imaging techniques. Maps 3 Software helps researchers move from large-area tissue overviews to targeted high-resolution imaging while preserving spatial context across imaging and analysis.

 

For pathology, cell biology, neuroscience, plant biology, correlative light and electron microscopy (CLEM), array tomography, or other volume electron microscopy (volume EM) applications, Maps 3 Software supports automated region-of-interest targeting, serial-section imaging, and data acquisition and correlation across imaging modalities within a single interactive project. The resulting connected data supports downstream 3D reconstruction and helps researchers build a more complete understanding of biological samples.

Correlative light and electron microscopy with Maps 3 Software

Maps 3 Software aligns fluorescence microscopy and TEM imaging data while preserving spatial context, helping researchers target regions of interest for high-resolution correlative analysis.

Key capabilities for biological research

  • Large-area tissue and whole-slide mapping
  • Automated region-of-interest targeting
  • Multi-scale navigation from tissue to ultrastructure
  • CLEM workflows
  • Volume EM and array tomography workflow support
  • Collaborative project review and handoff

 

More information

 

Maps 3 Software streamlines array tomography workflows

Maps 3 Software guides users through each step with dedicated workflow panels and automation for major acquisition tasks.


Maps 3 Software for semiconductor analysis

Modern semiconductor analysis requires multiple imaging and analytical techniques to identify, investigate, and characterize defects across increasingly smaller length scales. Maps 3 Software connects these activities in a single platform, helping engineers move from large-area overviews to targeted high-resolution imaging, elemental analysis, FIB milling, and advanced characterization while preserving spatial context.

 

For failure analysis, device characterization, process development, advanced packaging, defect localization, and cross section analysis, Maps 3 Software combines complementary imaging and analytical data within a single interactive project to support a more complete understanding of the device under investigation.

Quickly locate contamination with Maps 3 Software

Correlate large-area EDS maps with SEM images to quickly locate elemental contamination and investigate defects across packaged devices.

Key capabilities for semiconductor analysis

  • Large-area wafer mapping and navigation
  • Automated defect localization and targeted imaging
  • Multi-instrument and multimodal correlation
  • Targeted workflows for FIB cross-sectioning and analysis
  • Connected project documentation and collaboration

 

More information

 

Explore Thermo Scientific electron microscopes for the semiconductor industry.

 

Visualize material distribution

Correlate elemental maps with high-resolution SEM images to reveal material composition and support defect inspection, contamination analysis, and process optimization.


Talk to a specialist about your imaging workflow

Request a product demonstration, get a customized quote, or talk with a microscopy specialist about whether Maps 3 Software is right for your application and imaging needs.


How Maps 3 Software helps solve common microscopy challenges


Frequently asked questions about Maps 3 Software

Thermo Scientific Maps 3 Software is a connected microscopy platform that combines automated image acquisition, multi-scale navigation, multimodal data correlation, project management, and collaboration in one environment. It supports workflows across Thermo Scientific SEM, FIB-SEM, and TEM systems while keeping images, annotations, measurements, analytical results, and spatial context connected within a single project.

Correlative microscopy combines images and analytical data from multiple imaging modalities to offer a more complete understanding of a sample. Maps 3 Software preserves spatial context while correlating data from multiple analytical techniques, including SEM, TEM, FIB-SEM, light microscopy, Raman microscopy, EDS, and other compatible imaging systems, all within a single interactive project.

Maps 3 Software supports Thermo Scientific SEM, FIB-SEM, and TEM systems. It can also import and correlate data from many third-party imaging platforms and analytical techniques, including light microscopy, Raman microscopy, and EDS, so complementary images and analytical results can be interpreted within one interactive project.

Multimodal and correlative microscopy are useful when different instruments or techniques reveal complementary information about the same sample. Maps 3 Software aligns images and analytical data from multiple sources while preserving the location of each result on the sample. This allows observations from initial screening through advanced characterization to remain spatially connected.

Automated image acquisition is particularly useful for large-area mapping, multiple samples, serial sections, and other repetitive imaging tasks. Maps 3 Software can automate large-area, high-resolution acquisition, image stitching, region-of-interest targeting, and queued or unattended imaging sessions, helping reduce repetitive microscope operation while preserving spatial context.

Maps 3 Software features automated acquisition, multiscale navigation, multimodal correlation, connected project management, and offline review and collaboration. Consider adding the optional Maps Discover extension when the next imaging, measurement, or analytical step needs to change based on incoming data. Maps Discover analyzes data in real time and applies user-defined criteria to support adaptive, closed-loop workflows that can incorporate Python libraries, computer vision algorithms, and user-developed AI models.

The Maps Discover extension adds real-time analysis and acquisition feedback for adaptive, closed-loop microscopy workflows. Maps Discover Studio is the browser-based environment for creating, testing, refining, and deploying those workflows. Marie, the AI-assisted script helper, can transform natural-language workflow descriptions into MapsBridge Python code that researchers can review, test, and deploy to Maps Discover.

Yes. Researchers can review projects, annotate images, perform measurements, and share observations from a desktop without tying up valuable microscope time. Teams can continue reviewing and analyzing results while new data is acquired, supporting project handoffs and collaboration across users, laboratories, and locations.

For correlative light and electron microscopy, Maps 3 Software can align fluorescence microscopy data with electron microscopy imaging data while preserving spatial context. This helps researchers identify regions of interest with one imaging modality and target the same locations for high-resolution electron microscopy. For volume EM and array tomography, Maps 3 Software supports automated region-of-interest targeting, serial-section imaging, and image acquisition across multiple sections, producing aligned datasets for downstream visualization and analysis in Thermo Scientific Avizo or Amira Software.

For Research Use Only. Not for use in diagnostic procedures.