Antibodies that detect TRAIL-R2 (DR5) can be used in several scientific applications, including Western Blot, Immunohistochemistry (Paraffin), Flow Cytometry, ELISA and Immunocytochemistry. These antibodies target TRAIL-R2 (DR5) in Human, Mouse and Rat samples. Our TRAIL-R2 (DR5) monoclonal, polyclonal and recombinant monoclonal antibodies are developed in Mouse, Rabbit and Armenian Hamster. These antibodies have been verified by Cell treatment and Knockdown to confirm specificity to TRAIL-R2 (DR5). Find the TRAIL-R2 (DR5) antibody that fits your needs. Choose from 1 of 44 TRAIL-R2 (DR5) antibodies, which have been validated in experiments with 95 publications and 148 images featured in our data gallery.
Browse primary antibodies for WB, Flow, IHC, ICC/IF, ELISA, IP, and other applications. Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. If you cannot find the antibody you're looking for, contact us today to develop custom antibodies for specific targets, species and applications.
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DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a recently identified death domain containing receptor for TRAIL, which mediates TRAIL induced apoptosis. DR5 is a member of the TNF-receptor superfamily, and contains an intracellular death domain. DR5 can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by DR5. Two transcript variants encoding different isoforms of DR5 and one non-coding transcript have been found. Overexpression of DR5 induces apoptosis and activates NF-kappa-B. DR5 is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. Diseases associated with DR5 dysfunction include squamous cell carcinoma, and diffuse infiltrative lymphocytosis syndrome.
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