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Antibodies that detect TRAIL-R2 (DR5) can be used in several scientific applications, including Western Blot, Immunohistochemistry (Paraffin), Flow Cytometry, ELISA and Immunocytochemistry. These antibodies target TRAIL-R2 (DR5) in Human, Mouse and Rat samples. Our TRAIL-R2 (DR5) monoclonal, polyclonal and recombinant monoclonal antibodies are developed in Mouse, Rabbit and Armenian Hamster. These antibodies have been verified by Cell treatment and Knockdown to confirm specificity to TRAIL-R2 (DR5). Find the TRAIL-R2 (DR5) antibody that fits your needs. Choose from 1 of 44 TRAIL-R2 (DR5) antibodies, which have been validated in experiments with 95 publications and 148 images featured in our data gallery.
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DR5 (Apo2, TRAIL-R2, TRICK2, KILLER) is a recently identified death domain containing receptor for TRAIL, which mediates TRAIL induced apoptosis. DR5 is a member of the TNF-receptor superfamily, and contains an intracellular death domain. DR5 can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by DR5. Two transcript variants encoding different isoforms of DR5 and one non-coding transcript have been found. Overexpression of DR5 induces apoptosis and activates NF-kappa-B. DR5 is expressed in a number of cell types, and to particularly high levels in lymphocytes and spleen. Diseases associated with DR5 dysfunction include squamous cell carcinoma, and diffuse infiltrative lymphocytosis syndrome.
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