Chemokines are members of a superfamily of small inducible, secreted, pro-inflammatory cytokines. Members of the chemokine-like factor superfamily (CKLFSF) share similarities with both chemokine and transmembrane 4 superfamilies of signaling molecules. As a member of the CKLFSF family of proteins, CMTM1 (CKLF-like MARVEL transmembrane domain-containing protein 1), also known as CKLFSF1 (Chemokine-like factor superfamily member 1), is a 169 amino acid multi-pass membrane protein that is highly expressed in testis, therefore probably playing a role in spermatogenesis or testicular development. CMTM1 contains a CC-chemokine motif and four transmembrane segments. The gene encoding CMTM1 resides in a tight gene cluster on human chromosome 16 with CKLF, CMTM2, CMTM3 and CMTM4. There are at least sixteen isoforms of CMTM1 that are produced as a result of alternative splicing events.
chemokine-like factor super family 1; chemokine-like factor superfamily 1; Chemokine-like factor superfamily member 1; chemokine-like factor-like protein CKLFH1; CKLF-like MARVEL transmembrane domain containing 1; CKLF-like MARVEL transmembrane domain-containing protein 1