Cyclic AMP response element binding protein (CREB) is a basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation occurs via p44/42 MAP kinase and p90RSK and also via p38 MAP kinase and MSK1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133. CREB appears to play an important role in learning and memory.
InvitrogenCREB Antibody (3H8L15), ABfinity™ Rabbit Monoclonal CREB Antibody (3H8L15), ABfinity™ Rabbit Monoclonal
Cat # 701120
InvitrogenCREB Antibody (3HCLC), ABfinity™ Rabbit Oligoclonal CREB Antibody (3HCLC), ABfinity™ Rabbit Oligoclonal
Cat # 710149
InvitrogenPhospho-CREB (Ser133) Antibody (B16H16L26), ABfinity™ Rabbit Monoclonal Phospho-CREB (Ser133) Antibody (B16H16L26), ABfinity™ Rabbit Monoclonal
Cat # 700129
InvitrogenPhospho-CREB (Ser133) Monoclonal Antibody (F.959.4) Phospho-CREB (Ser133) Monoclonal Antibody (F.959.4)
Cat # MA5-11192
InvitrogenPhospho-CREB (Ser133) Monoclonal Antibody (C.744.2) Phospho-CREB (Ser133) Monoclonal Antibody (C.744.2)
Cat # MA5-15223
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