The product of the DEGS1 gene is a member of the membrane fatty acid (sphingolipid delta 4 ) desaturase family. Reported to function by inserting double bonds at delta 4 position in fatty acids. DEGS1 is an intracellular enzyme. Overexpression of this gene inhibited biosynthesis of the EGF receptor, suggesting a possible role of a fatty acid desaturase in regulation biosynthetic processing of the EGF receptor. Two splice variants have been identified.
Cell migration-inducing gene 15 protein; Degenerative spermatocyte homolog 1; degenerative spermatocyte homolog 1, lipid desaturase; degenerative spermatocyte homolog, lipid desaturase; Degenerative spermatocyte-like protein RDES; Delta(4)-desaturase; delta(4)-desaturase, sphingolipid 1; dihydroceramide desaturase; dihydroceramide desaturase 1; DSH1; membrane fatty acid (lipid) desaturase; Membrane lipid desaturase; MGC5079; migration-inducing gene 15 protein; sphingolipid 1; sphingolipid delta 4 desaturase; sphingolipid delta(4)-desaturase 1; Sphingolipid delta(4)-desaturase DES1; sphingolipid delta(4)-desaturase DES1-like
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