Dynorphin A immunoreactive cells are found in the paraventricular and supraoptic nucleus and in hippocampal mossy fibers of rat brain following kainic acid administration and colchicine induced neurotoxicity. Dynorphins play a role in multiple physiologic processes including pain perception and responses to stress. They mimic and compete with a number of opiate drugs. Dysregulation of dynorphin A expression has been linked to progression of neurodegenerative conditions such as Alzheimerâ€™s disease and appears to play a significant role in the pathobiology of epilepsy.
Alpha-neoendorphin; Beta-neoendorphin; Beta-neoendorphin-dynorphin; Big Dyn; Big dynorphin; Dyn-A17; Dyn-B; Dynorphin A(1-13); Dynorphin A(1-17); Dynorphin A(1-8); Dynorphin B; Dynorphin B(1-13); Dynorphin B-29; Leu-enkephalin; Leumorphin; MGC26418; neoendorphin-dynorphin-enkephalin prepropeptide; PENKB; Preprodynorphin; preproenkephalin B; proenkephalin B; Proenkephalin-B; Rimorphin