This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
CD221; IGF-I receptor; IGFIR; IGFR; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; JTK13; soluble IGF1R variant 1; soluble IGF1R variant 2
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