This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X.
46 kDa mannose 6-phosphate receptor; 46-kDa mannose 6-phosphate receptor; Cation-dependent mannose-6-phosphate receptor; CD Man-6-P receptor; mannose-6-phosphate receptor (cation dependent); MPR 46; Mr 46,000 Man6PR; small mannose 6-phosphate receptor