The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.
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77kDa; Activator-recruited cofactor 77 kDa component; ARC77; cofactor required for Sp1 transcriptional activation; Cofactor required for Sp1 transcriptional activation subunit 6; cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa; CRSP complex subunit 6; CRSP6; CRSP77; DRIP80; Mediator complex subunit 17; Mediator of RNA polymerase II transcription subunit 17; subunit 6; thyroid hormone receptor-associated protein complex 80; Thyroid hormone receptor-associated protein complex 80 kDa component; Transcriptional coactivator CRSP77; TRAP80; Vitamin D3 receptor-interacting protein complex 80 kDa component