LTB4DH functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. It has no activity towards PGE1, PGE2 and PGE2-alpha. LTB4DH catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4.
15-oxoprostaglandin 13-reductase; leukotriene B4 12-hydroxydehydrogenase; LTB4DH; NADP-dependent leukotriene B4 12-hydroxydehydrogenase; PGR1; PRG-1; Prostaglandin reductase 1; ZADH3; zinc binding alcohol dehydrogenase domain containing 3