PTGR1 encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants.
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Protein Aliases: 15-oxoprostaglandin 13-reductase; D3T-inducible gene 1 protein; DIG-1; Dithiolethione-inducible gene 1 protein; dithiolethione-inducible gene-1; FLJ99229; leukotriene B4 12-hydroxydehydrogenase; MGC34943; NADP-dependent leukotriene B4 12-hydroxydehydrogenase; PRG-1; Prostaglandin reductase 1; zinc binding alcohol dehydrogenase domain containing 3
Gene Aliases: 2510002C21Rik; Dig1; LTB4DH; PGR1; PTGR1; ZADH3