PTP beta, also known as Receptor-type tyrosine-protein phosphatase beta [Precursor], Protein-tyrosine phosphatase beta,R-PTP-beta, PTPRB or PTPB is a protein tyrosine phosphatase and is overexpressed in glioblastoma tumors. PTP beta plays a n important functional role in tumor cell migration and adhesion. Glioblastomas express at least three splice variants of PTPbeta, including long and short receptor forms. The short form of PTPbeta lacks exon 12, which encodes 860 amino acids located in the extracellular domain. In normal brain tissue and graded astrocytomas the long and short PTPbeta forms have an overlapping expression pattern. U87 stable cell lines overexpressing long or short PTPbeta migrate faster and adhere more robustly than parental U87 cells. The involvement of long and short PTPbeta in glioma tumor cell biology also contributes to the value of PTPbeta as a cancer target.
protein tyrosine phosphatase, receptor type, B; protein tyrosine phosphatase, receptor type, beta polypeptide; Protein-tyrosine phosphatase beta; PTPB; Receptor-type tyrosine-protein phosphatase beta; Vascular endothelial protein tyrosine phosphatase; VE-PTP