Orphan receptor. Could be a receptor for trace amines. Of the biogenic trace amine tested, activated only by beta-phenylethylamine (beta-PEA) and tryptamine; however, the response is of low potency. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. This receptor seems to be mediated by the G(s)-class of G-proteins which activate adenylate cyclase.
2-phenylethylamine receptor; Gm226; mTaar4; Ta2; TAAR 4; TaR-2; TaR-4; trace amine associated receptor 4; Trace amine receptor 2; trace amine receptor 4; Trace amine-associated receptor 4; trace-amine-associated receptor 4