TRAFs are signal transducers for members of TNFR superfamily. These are critically involved in activation of MAP3K family members involved in NF-kappaB and JNK activation and apoptosis. TRAF7, a novel 670 A.A protein, is a human homolog of mouse Traf7 and consists of an N-terminal RING finger domain, central TRAF domain, a coiled-coil motif and 7 WD40 repeats at the C-terminus. It has E3-ubiquitin ligase activity for self-ubiquitination. TRAF7 specifically interacts with MEKK3 and mediates MEKK3-induced AP1 and CHOP activation and induces apoptosis through Caspase-independent pathways.It is a multifunctional protein involved in sumoylation and negative regulation of c-Myb, thereby regulating proliferation and differentiation of hematopoietic cells.
DKFZp586I021; E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase TRAF7; MGC7807; RFWD1; ring finger and WD repeat domain 1; RING finger and WD repeat-containing protein 1; RING finger protein 119; RING-type E3 ubiquitin transferase TRAF7; RNF119; TNF receptor-associated factor 7; TNF receptor-associated factor 7, E3 ubiquitin protein ligase