EAR2 Antibodies

Target Information

Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).

Synonyms

AV090102; avian erythroblastic leukemia viral (v-erb-a) oncogene homolog-like 2; COUP transcription factor 3; COUPg; COUP-TF3; EAR2; EAR-2; Erba related 2; ERBAL2; ERBA-related gene-2; Nr2f6; Nuclear receptor subfamily 2 group F member 6; nuclear receptor subfamily 2, group F, member 6; nuclear receptor V-erbA-related; orphan nuclear receptor EAR-2; Ovalbumin upstream promoter gamma nuclear receptor; ovalbumin upstream promoter gamma nuclear receptor rCOUPg; v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 2; V-erbA-related protein 2; V-erbA-related protein EAR-2