Histone Core Antibodies

Target Information

The histone core is an integral component of chromatin structure, consisting of an octamer of core histones: H2A, H2B, H3, and H4. Each nucleosome unit contains two copies of each of these histones, forming a structural foundation around which approximately 147 base pairs of DNA are wrapped. The histone octamer is organized with an (H3-H4)2 tetramer at its core, flanked by two H2A-H2B dimers. This highly conserved structure not only facilitates DNA compaction but also plays a critical role in regulating gene expression through various post-translational modifications, such as acetylation, methylation, and phosphorylation. These modifications can alter chromatin dynamics and accessibility, impacting processes such as transcription, replication, and DNA repair. The presence of specific histone variants further adds to the epigenetic complexity and regulation of the genome.

Synonyms

core histone macro-H2A.1; H2A histone family, member Y; H2AFY; H2B; H2B clustered histone 19; H2B clustered histone 8; H2BC19; H2BC8; H3 histone, family 3A; H3.3 histone A; H3-3A; H3-3B; H3F3A; H3F3B; H4; H4 clustered histone 2; H4.1; H4C2; histone H2B; histone H2B type 1; histone H2B type 2-E; histone H2B-like; histone H3.3; Histone H4; histone H4.1; macroH2A.1 histone; MACROH2A1; similar to H2A histone family, member Y isoform 2; similar to H3 histone, family 3A