G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
5-HT-1E; 5-HT1E; 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled; 5-hydroxytryptamine receptor 1E; S31; Serotonin receptor 1E