LY6G6D/CD3 Antibodies

Target Information

G6D, also known as Lymphocyte antigen 6 complex locus G6D (LY6G6D), is a type I transmembrane protein belonging to the immunoglobin (Ig) superfamily, that is comprised of cell-surface proteins involved in the immune system and cellular recognition. It is a disulfide linked homodimer with an Ig-like V-type domain and is known to interact with GRB2 and GRB7 in a phosphorylation-dependent manner thus playing an important role in their downstream signal transduction pathways.

The CD3 complex, composed of gamma, delta, epsilon, and zeta subunits, is essential for the assembly, trafficking, and surface expression of the T cell receptor (TCR) complex. These subunits are structurally related members of the immunoglobulin superfamily and are encoded by closely linked genes on human chromosome 11. CD3 is expressed by thymocytes in a developmentally regulated manner and by all mature T cells, but not on B or NK cells. The CD3 subunits play a crucial role in transducing antigen-recognition signals into the cytoplasm of T cells. The cytoplasmic tails of CD3 subunits contain a double tyrosine-based motif that associates with cytoplasmic signal transduction molecules, mediating T cell activation through the TCR. Crosslinking of the TCR initiates intracellular biochemical pathways that result in cellular activation, proliferation, and potentially growth arrest and cell survival. CD3 is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes, and Purkinje cells in the cerebellum. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. Defects in the CD3 gene are associated with CD3 immunodeficiency, highlighting its importance in immune function and regulation.