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MAP4K5 (KHS1) is a serine/threonine kinase that belongs to the GCK family of kinases and has been implicated as an upstream regulator of MAP kinase signaling pathways. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for MAP4K5.
4432415E19Rik; fl74c10; GCKR; germinal center kinase-related; KHS; KHS1; Kinase homologous to SPS1/STE20; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 5; map4k5; MAPK/ERK kinase kinase kinase 5; MAPKKKK5; MEK kinase kinase 5; MEKKK 5; mitogen-activated protein kinase kinase kinase kinase 5; RGD1562028; wu:fl74c10; zgc:55719; zgc:55985
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