NFkB p100 Antibodies

Target Information

This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants.

Synonyms

CVID10; DNA-binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10 protein; lyt; Lyt10; LYT-10; NF kappaB2; NF-kappaB2; NF-kB p100; NFKB, p52/p100 subunit; NFKB2; NF-kB2; nuclear factor kappa B subunit 2; nuclear factor Kappa-B, subunit 2; nuclear factor NF-kappa-B p100 subunit; Nuclear factor NF-kappa-B p52 subunit; nuclear factor of Kappa light chain gene enhancer in B cells 2; nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100); nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100; oncogene Lyt-10; p100; p49; p49/p100; p50B; p52; RGD1307189; transcription factor NFKB2