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Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Specifically involved in maintaining stability of STT3A-containing OST complexes.
2310016E02Rik; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4; oligosaccharyltransferase 4 homolog; oligosaccharyltransferase 4 homolog (S. cerevisiae); oligosaccharyltransferase complex subunit 4 (non-catalytic); oligosaccharyltransferase complex subunit 4, non-catalytic; OST4
100 µL
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