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Invitrogen
CD132 Monoclonal Antibody (TUGh4), Biotin, eBioscience™
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FIGURE: 1 / 1
CD132 Antibody (13-1329-82) in Flow
Staining of normal human peripheral blood cells with anti-human CD4 eFluor® 450 (Product # 48-0049-42) and Rat IgG2b K Isotype Control Biotin (Product # 13-4031-82) (left) or Anti-Human CD132 Biotin (right) followed by Streptavidin PE (Product # 12-4317-87). Cells in the lymphocyte gate were used for analysis.
Product Details
13-1329-82
Product Specifications
Species Reactivity
Human
Host/Isotype
Rat
/ IgG2b, lambda
Recommended Isotype Control
Class
Monoclonal
Type
Antibody
Clone
TUGh4
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.09% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Description: This TUGh4 monoclonal antibody reacts with human CD132, the common gamma chain (gamma c) shared by the IL-2, IL-4, IL-7, IL-9, and IL-15 receptors. This approximately 65 kDa receptor component is expressed on T and B lymphocytes, NK cells, monocytes, and granulocytes. CD132 is involved in intracellular signal transduction by associating with effector molecules within the cytoplasm. Mutations in the human gamma chain gene result in X-linked severe combined immunodeficiency (XSCID), a disease characterized by T cell deficiency leading to impairment of cell-mediated and humoral immunity.
Applications Reported: This antibody has been reported for use in flow cytometric analysis.
Applications Tested: This TUGh4 antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 0.125 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
IL2RG is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD132; CD132 antigen; common cytokine receptor gamma chain; Cytokine receptor common subunit gamma; gammaC; IL-2 receptor subunit gamma; IL-2R subunit gamma; IL2R gamma; interleukin 2 receptor, gamma; Interleukin-2 receptor subunit gamma; nonfunctional common cytokine receptor gamma chain; p64; unnamed protein product
Gene Aliases: CD132; CIDX; IL-2RG; IL2RG; IMD4; P64; SCIDX; SCIDX1
UniProt ID: (Human) P31785
Entrez Gene ID: (Human) 3561
mature B cell differentiation
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
immune system process
positive regulation of immunoglobulin production
immune response
signal transduction
gene expression
regulation of gene expression
positive regulation of gene expression
cytokine-mediated signaling pathway
cellular homeostasis
lymphocyte differentiation
B cell differentiation
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
T cell differentiation in thymus
positive regulation of T cell differentiation in thymus
interleukin-15-mediated signaling pathway
interleukin-4-mediated signaling pathway
interleukin-2-mediated signaling pathway
interleukin-7-mediated signaling pathway
interleukin-9-mediated signaling pathway
positive regulation of B cell differentiation
positive regulation of phagocytosis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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