PA5-29689 targets 14-3-3 beta in IF, IHC (P), and WB applications and shows reactivity with Human and mouse samples.
The PA5-29689 immunogen is recombinant fragment corresponding to a region within amino acids 34 and 246 of Human 14-3-3 beta.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene.
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Protein Aliases: 14-3-3 alpha; 14-3-3 protein beta; 14-3-3 protein beta/alpha; 14-3-3 protein beta/alpha, N-terminally processed; alpha polypeptide; beta isoform; brain protein 14-3-3; brain protein 14-3-3, beta isoform; epididymis secretory protein Li 1; GW128; HS1; KCIP-1; Protein 1054; Protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, beta polypeptide; YWHAA
Gene Aliases: 1300003C17Rik; GW128; HEL-S-1; HS1; KCIP-1; YWHAA; YWHAB
Molecular Function: chaperone