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Invitrogen
Claudin 4 Monoclonal Antibody (3E2C1), Alexa Fluor™ 488
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FIGURE: 1 / 2
Claudin 4 Antibody (329488) in IHC (P)
Immunohistochemistry analysis of Claudin 4 showing staining in the tight junctions of paraffin-embedded human colon tissue. To expose target proteins, antigen retrieval was performed by heating the tissue to 95 C in 10mM sodium citrate (pH 6.0) for 20 min. Following antigen retrieval, tissues were blocked in 3% H2O2 for 10 min at room temperature, washed with ddH2O and PBS, and then blocked with 10% goat se... View More
Product Details
329488
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Mouse,
Rat
Published species
Dog,
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3E2C1
Immunogen
Synthetic peptide corresponding to a 22 amino acid sequence derived from the C-terminal region of human Claudin-4.
Conjugate
Excitation/Emission Max
499/520 nm
View spectra
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Claudin-4 belongs to the 20-member family of claudins, transmembrane cellular adhesion proteins localized at epithelial and endothelial tight junctions. Claudins demonstrate distinct, tissue-specific expression patterns, and are essential components of tight junction charge-specific channels that regulate paracellular ion flux. Claudin-4 is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. The overexpression of Claudin-4 has been shown to decrease paracellular electrical conductance due to a selective decrease in Na+ permeability, with no significant decrease in Cl- permeability. In ovarian carcinoma cells, Claudin-3 and Claudin-4 exhibit upregulation at both mRNA and protein levels. Claudin-4 is also overexpressed in pancreatic cancer tissues and cell lines, and in other epithelial cancers. The Claudin-4 gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Claudin-4; CLAUDIN4; Clostridium perfringens enterotoxin receptor; Clostridium perfringens enterotoxin receptor 1; CPE-R; CPE-receptor; h CPE-receptor; unnamed protein product; Williams-Beuren syndrome chromosomal region 8 protein
Gene Aliases: Cep-r; CLDN4; CPE-R; CPER; CPETR; CPETR1; hCPE-R; WBSCR8
UniProt ID: (Human) O14493, (Dog) A0A8C0N7E5, (Mouse) O35054
Entrez Gene ID: (Human) 1364, (Dog) 100856416, (Rat) 304407, (Mouse) 12740
ion transport
chloride transport
cell adhesion
female pregnancy
circadian rhythm
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
regulation of cell morphogenesis
positive regulation of cell migration
response to progesterone
ion transmembrane transport
establishment of skin barrier
renal absorption
bicellular tight junction assembly
positive regulation of wound healing
paracellular transport
chloride transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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