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Invitrogen
Connexin 26 Monoclonal Antibody (CX-1E8)
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FIGURE: 1 / 77
Connexin 26 Antibody (33-5800) in IHC
Immunofluorescence analysis of connexin 26 was performed on sections of adult mouse liver. Tissue sections on slides were probed for 24 h at 4°C in a humidified chamber with a mouse monoclonal anti-Cx26 (Product # 33-5800), at an antibody concentration of 1-2 µg/mL diluted in 50 mM Tris-HCl, pH 7.4, containing 1.5% NaCl, 0.3% Triton X-100 (TBST) and 4% normal goat serum. After overnight incubation, sections... View More
Product Details
33-5800
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Published species
Chicken,
Guinea pig,
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
CX-1E8
Immunogen
A 13 amino acid synthetic peptide derived from the C-terminus of the mouse Connexin 26 protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
33-5800 was used in the immunofluorescence and western blot analysis to successfully detect Connexin26 in mouse liver sections and homogenate, respectively.
Target Information
Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels. Defects in GJB3 have been linked to erythrokeratodermia variables (EKV) is an autosomal dominant genodermatosis characterized by transient figurate red patches or hyperkeratosis. Mutations in GJB2 have also been associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: connexin 26; Connexin-26; Cx26; Gap junction beta-2 protein; gap junction channel protein connexin 26; gap junction membrane channel protein beta 2
Gene Aliases: AI325222; Cnx26; Cx26; CXN-26; Gjb-2; Gjb2
UniProt ID: (Mouse) Q00977, (Rat) P21994
Entrez Gene ID: (Mouse) 14619, (Rat) 394266
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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