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Invitrogen
Cyclophilin A Monoclonal Antibody (ZC001)
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FIGURE: 1 / 5
Cyclophilin A Antibody (39-1100) in WB
Western blot analysis of Cyclophin A was performed using whole cell lysates of HeLa (Lane 1) and NIH/3T3 (Lane 2). The blots were probed with Anti- Cyclophilin A Mouse Monoclonal Antibody (Product # 39-1100, 1:250 dilution) and detected by chemiluminescence using Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, HRP conjugate (Product # A28177, 0.4 µg/mL, 1:2500 dilution). A ~ 18 kDa band corresponding to Cyclophilin A were observed across cell lines tested. Known quantity of protein samples were electrophoresed using Novex® NuPAG... View More
Product Details
39-1100
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
ZC001
Immunogen
Recombinant protein containing the N-terminal region of human cyclophilin A
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
tissue culture supernatant
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins. Within the cyclophilin family, there are several different proteins which show a high degree of homology including CyPA, CyPB and CyPC. CyPA, also termed CyP-18, is the most abundant and ubiquitous cyclophilin found in all vertebrate tissues and is present in T-cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cyclophilin; Cyclophilin A; Cyclosporin A-binding protein; CyP A; EC 5.2.1.8; epididymis secretory sperm binding protein Li 69p; HGNC:9253; MGC117158; MGC12404; MGC23397; Peptidyl-prolyl cis-trans isomerase A; peptidylprolyl isomerase A (cyclophilin A); PPIA; PPIase; PPIase A; rotamase; Rotamase A; SP18; T cell cyclophilin; unnamed protein product
Gene Aliases: 2700098C05; Cphn; CyP-18; CYPA; CYPH; HEL-S-69p; PPIA
UniProt ID: (Human) P62937, (Mouse) P17742
Entrez Gene ID: (Human) 5478, (Mouse) 268373
protein peptidyl-prolyl isomerization
negative regulation of protein phosphorylation
positive regulation of protein phosphorylation
protein folding
negative regulation of protein kinase activity
apoptotic process
viral release from host cell
platelet activation
neuron differentiation
neutrophil chemotaxis
leukocyte chemotaxis
activation of protein kinase B activity
negative regulation of stress-activated MAPK cascade
lipid particle organization
cellular response to oxidative stress
endothelial cell activation
positive regulation of MAPK cascade
regulation of viral genome replication
positive regulation of viral genome replication
positive regulation of protein secretion
positive regulation of NF-kappaB transcription factor activity
cell adhesion molecule production
negative regulation of protein K48-linked ubiquitination
platelet aggregation
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
negative regulation of viral life cycle
regulation of apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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