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Invitrogen
PPBP Monoclonal Antibody, PeproTech®
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FIGURE: 1 / 3
PPBP Antibody (500-M33-500UG) in WB
Western Blot: To detect Human NAP-2 (CXCL7) by Western Blot analysis PPBP Monoclonal Antibody (Product # 500-M33-500UG) can be used at a concentration of 0.5-1.0 µg/mL. When used in conjunction with compatible secondary reagents the detection limit for Recombinant Human NAP-2(CXCL7) is 0.5-1.0 ng/lane, under reducing or non-reducing conditions.
Product Details
500-M33-500UG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
Class
Monoclonal
Type
Antibody
Immunogen
E.coli-derived Recombinant Human NAP-2 (CXCL7)
Conjugate
Form
Lyophilized
Amount
500 µg
Purification
Protein G
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient
RRID
Product Specific Information
AA Sequence of recombinant protein: AELRCMCIKT TSGIHPKNIQ SLEVIGKGTH CNQVEVIATL KDGRKICLDP DAPRIKKIVQ KKLAGDESAD.
Preparation: Produced in mice immunized with highly pure Recombinant Human NAP-2 (CXCL7). Anti-Human NAP-2 (CXCL7)-specific antibody was purified from cell culture by Protein G affinity chromatography.
Target Information
Members of the a-chemokine subfamily of inducible, secreted, pro-inflammatory cytokines contain a similar motif, in which the first two cysteine residues are separated by a single residue (Cys-X-Cys), and are also chemotactic for neutrophils. The platelet basic protein (PBP), a member of the a-chemokine family, resides in the a-granules of platelets and is released upon their activation. Proteolytic cleavage of the amino terminus of PBP leads to the generation of several peptides, which include mature PBP, connective tissue-activating peptide III (CTAP III, also designated low affinity platelet factor IV (LA-PF4)), b-thromboglobulin (b-TG), and neutrophil-activating peptide 2 (NAP-2). PBP and its N-truncated derivatives mediate inflammation and wound healing. Specifically, NAP-2 activates chemotaxis and degranulation in neutrophils during inflammation. The gene encoding human PBP maps to chromosome 4q12-q13.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: beta-thromboglobulin; C-X-C motif chemokine 7; chemokine (C-X-C motif) ligand 7; connective tissue-activating peptide III; CXC chemokine ligand 7; LDGF; Leukocyte-derived growth factor; low-affinity platelet factor IV; Macrophage-derived growth factor; MDGF; neutrophil-activating peptide 2; PBP; Platelet basic protein; PPBP; small inducible cytokine B7; small inducible cytokine subfamily B, member 7; Small-inducible cytokine B7; thrombocidin 1; thrombocidin 2; thromboglobulin, beta-1; unnamed protein product
Gene Aliases: B-TG1; Beta-TG; CTAP-III; CTAP3; CTAPIII; CXCL7; LA-PF4; LDGF; MDGF; NAP-2; PBP; PPBP; SCYB7; TC1; TC2; TGB; TGB1; THBGB; THBGB1
UniProt ID: (Human) P02775
Entrez Gene ID: (Human) 5473
chemotaxis
defense response
inflammatory response
immune response
signal transduction
neutrophil chemotaxis
killing of cells of other organism
defense response to bacterium
positive regulation of cell division
antimicrobial humoral immune response mediated by antimicrobial peptide
cellular response to lipopolysaccharide
glucose transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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