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|Tested species reactivity||Human, Mouse, Rat|
|Published species reactivity||Not Applicable|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide of human tumor protein p53 binding protein 1 region encoded exon 19 (LocusLink ID 7158)|
|Purification||Antigen affinity chromatography|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|ChIP assay (ChIP)||Assay-Dependent|
|Immunohistochemistry (Frozen) (IHC (F))||Assay-Dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||1:10-1:500|
|Western Blot (WB)||1:2000-1:10,000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (Paraffin) (IHC (P))||See 1 publications below|
Human samples have been tested in Western Blot and ICC/IF, and mouse samples have been tested in ICC/IF only.
Suggested positive control: U205, 293T, and MO59K cell lysates and MEF lysates .
P53-binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to the presumptive sites of damage, specifically, double-strand breaks. This also suggests a role in DNA repair, maintaining genomic stability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Exposure to heavy ion radiation induces persistent oxidative stress in mouse intestine.
PA1-16566 was used in immunohistochemistry - paraffin section to determine if long-term oxidative stress in freshly isolated mouse intestinal epithelial cells is dependent on radiation quality at a dose relevant to fractionated radiotherapy
|Datta K,Suman S,Kallakury BV,Fornace AJ||PloS one (7:null)||2012|
53BP1; murine p53-binding protein; p202; p53-binding protein 1; TP53BP1; transformation related protein 53 binding-protein 1; tumor protein 53-binding protein, 1; tumor protein p53-binding protein, 1; Tumor suppressor p53-binding protein 1
53BP1; m53BP1; p202; p53BP1; TDRD30; TP53; TP53BP1; Trp53bp1