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5HT2A R Polyclonal Antibody
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Product Details
OSS00188W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from c-terminal region of human 5HT2A receptor conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: 5HT2A receptor.
Target Information
In platelets and gut, serotonin plays a major role in cardiovascular function and motility of the gastrointestinal tract, respectively. Serotonin mediates its effects through several of G protein coupled receptors, designated 5-HT receptors or alternatively SR receptors. The SR-2 receptors are comprised of three subtypes, SR-2A, SR-2B and SR-2C, which activate phospholipase C and release intracellular stores of calcium in response to serotonin. SR-2A has a specific role in tracheal smooth muscle contraction, bronchoconstriction and mediating aldosterone production, and it is also thought to play a role in several psychiatric disorders, including depression and schizophrenia. SR-2B is expressed in embryonic and adult cardiovascular tissues, gut and brain and plays an important role in the pathology of cardiac disorders. SR-2C is thought to mediate the effects of atypical antipsychotic drugs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 5-HT-2; 5-HT2 receptor; 5-HT2A/2C; 5-HT2A/2C receptor; 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled; 5-hydroxytryptamine receptor 2A; 5HT2A Receptor; serotonin 5-HT-2A receptor; serotonin receptor; Serotonin receptor 2A; SR2A; unnamed protein product
Gene Aliases: 5-HT2A; HTR2; HTR2A
UniProt ID: (Human) P28223
Entrez Gene ID: (Human) 3356
Gq/11-coupled serotonin receptor activity
virus receptor activity
G-protein coupled receptor activity
G-protein coupled serotonin receptor activity
protein binding
protein tyrosine kinase activator activity
neurotransmitter receptor activity
identical protein binding
macromolecular complex binding
serotonin binding
1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding
serotonin receptor activity
temperature homeostasis
positive regulation of cytokine production involved in immune response
glycolytic process
cellular calcium ion homeostasis
signal transduction
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
positive regulation of cytosolic calcium ion concentration
phospholipase C-activating serotonin receptor signaling pathway
serotonin receptor signaling pathway
chemical synaptic transmission
memory
positive regulation of cell proliferation
response to xenobiotic stimulus
positive regulation of phosphatidylinositol biosynthetic process
regulation of dopamine secretion
artery smooth muscle contraction
urinary bladder smooth muscle contraction
positive regulation of heat generation
response to cocaine
negative regulation of potassium ion transport
positive regulation of neuron apoptotic process
protein localization to cytoskeleton
positive regulation of fat cell differentiation
positive regulation of glycolytic process
positive regulation of vasoconstriction
viral entry into host cell
sensitization
behavioral response to cocaine
positive regulation of inflammatory response
sensory perception of temperature stimulus
detection of temperature stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception of pain
release of sequestered calcium ion into cytosol
negative regulation of synaptic transmission, glutamatergic
positive regulation of ERK1 and ERK2 cascade
G protein-coupled serotonin receptor signaling pathway
presynaptic modulation of chemical synaptic transmission
positive regulation of execution phase of apoptosis
positive regulation of platelet aggregation
positive regulation of DNA biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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