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5HT7 R Polyclonal Antibody
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FIGURE: 1 / 2
5HT7 R Antibody (OSS00205W-100UL) in IHC (P)
IHC-P on paraffin sections of rat brain. The animal was perfused using Autoperfuser at a pressure of 130 mmHg with 300 mL 4% FA being processed for paraffin embedding. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturers instructions; DAB chromogen: Candela DAB chromogen fro... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
OSS00205W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Guinea pig,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from human 5HT7 R conjugated to blue carrier protein was used as the antigen
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in rat, mouse and guinea pig.
Specificity of this antibody: 5HT7R receptor.
Target Information
5-HT7 Receptor is a Serotonin Receptor with several functions, including regulation of the circadian rhythm and mediation of smooth-muscle relaxation in the vasculature and GI tract. This receptor has been implicated in depression, autism, and other neuropsychiatric disorders. Three protein isoforms have been documented: isoform a: 445aa; isoform b: 432aa; isoform d: 479aa. 5-HT7 Receptor has been reported in aorta, brain, heart, placenta, small intestine, spleen, artery, and vessel. An EST has been isolated from a testis library.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 5-HT-7; 5-HT-X; 5-HT7; 5-HT7 receptor; 5-hydroxytryptamine receptor 7; 5-hydroxytryptamine7 receptor; 5HT7 Receptor; GPRFO; high affinity serotonin receptor (5HT7); HT7; OTTHUMP00000020077; OTTHUMP00000020078; OTTHUMP00000020079; Serotonin receptor 7
Gene Aliases: 5-HT7; 5Ht7; HTR7
UniProt ID: (Mouse) P32304, (Rat) P32305, (Guinea pig) P50407
Entrez Gene ID: (Mouse) 15566, (Rat) 65032, (Guinea pig) 100135549
smooth muscle contraction
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-activating serotonin receptor signaling pathway
serotonin receptor signaling pathway
chemical synaptic transmission
memory
circadian rhythm
positive regulation of neuron projection development
negative regulation of serotonin secretion
urinary bladder smooth muscle contraction
vasoconstriction
negative regulation of circadian sleep/wake cycle, REM sleep
behavioral response to pain
detection of mechanical stimulus involved in sensory perception of pain
response to corticosterone
micturition
long-term synaptic potentiation
dopaminergic neuron differentiation
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
response to electrical stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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