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Proteintech
KEAP1 Monoclonal Antibody (4G10H9)
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Product Details
60027-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgA
Class
Monoclonal
Type
Antibody
Clone
4G10H9
Immunogen
KEAP1 Fusion Protein Ag0779 (325-624 aa encoded by BC002930)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
75 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is a mouse monoclonal antibody raised against residues near the C terminus of human KEAP1.
Immunogen sequence: GRLIYTAGG YFRQSLSYLE AYNPSDGTWL RLADLQVPRS GLAGCVVGGL LYAVGGRNNS PDGNTDSSAL DCYNPMTNQW SPCAPMSVPR NRIGVGVIDG HIYAVGGSHG CIHHNSVERY EPERDEWHLV APMLTRRIGV GVAVLNRLLY AVGGFDGTNR LNSAECYYPE RNEWRMITAM NTIRSGAGVC VLHNCIYAAG GYDGQDQLNS VERYDVETET WTFVAPMKHR RSALGITVHQ GRIYVLGGYD GHTFLDSVEC YDPDTDTWSE VTRMTSGRSG VGVAVTMEPC RKQIDQQNCT C (325-624 aa encoded by BC002930)
Target Information
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cytosolic inhibitor of Nrf2; INRF2; KEAP1 delta C; Kelch-like ECH-associated protein 1; kelch-like family member 19; Kelch-like protein 19; KIAA0132; NRF2 cytosolic inhibitor; ring canal protein; unnamed protein product
Gene Aliases: INRF2; KEAP1; KIAA0132; KLHL19; mKIAA0132
UniProt ID: (Human) Q14145, (Mouse) Q9Z2X8
Entrez Gene ID: (Human) 9817, (Mouse) 50868, (Rat) 117519
protein binding
identical protein binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
disordered domain specific binding
transcription regulator inhibitor activity
protein binding, bridging involved in substrate recognition for ubiquitination
transcription factor binding
scaffold/adaptor protein
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
regulation of transcription, DNA-templated
ubiquitin-dependent protein catabolic process
response to oxidative stress
regulation of autophagy
protein ubiquitination
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
cellular response to oxidative stress
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of epidermal cell differentiation
protein K48-linked ubiquitination
cellular response to interleukin-4
negative regulation of response to oxidative stress
transcription, DNA-templated
proteasomal ubiquitin-independent protein catabolic process
negative regulation of gene expression
positive regulation of cellular protein metabolic process
cytoplasmic sequestering of transcription factor
protein oligomerization
selenium compound metabolic process
malate metabolic process
flavonoid metabolic process
response to metal ion
alkanesulfonate metabolic process
response to immobilization stress
cellular response to organic cyclic compound
response to thyroid hormone
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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