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Proteintech
Galectin-3 Monoclonal Antibody (1C1B2)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
60207-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1C1B2
Immunogen
Galectin-3 Fusion Protein Ag6753 (1-250 aa encoded by BC001120)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.83 mg/mL
Amount
124.5 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MADNFSLHD ALSGSGNPNP QGWPGAWGNQ PAGAGGYPGA SYPGAYPGQA PPGAYPGQAP PGAYPGAPGA YPGAPAPGVY PGPPSGPGAY PSSGQPSATG AYPATGPYGA PAGPLIVPYN LPLPGGVVPR MLITILGTVK PNANRIALDF QRGNDVAFHF NPRFNENNRR VIVCNTKLDN NWGREERQSV FPFESGKPFK IQVLVEPDHF KVAVNDAHLL QYNHRVKKLN EISKLGISGD IDLTSASYTM I (1-250 aa encoded by BC001120)
Target Information
Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 34 kDa beta-galactoside-binding lectin (L-34); 35 kDa lectin; advanced glycation end-product receptor 3; carbohydrate binding protein 35; carbohydrate-binding protein 35; CBP 35; CBP-30; epididymis secretory sperm binding protein; epithelial-specific lectin; epsilon BP; gal-3; galactose-specific lectin 3; Galectin3; IgE binding protein; IgE-binding protein; L-29; L-34 galactoside-binding lectin; laminin-binding protein; lectin galactoside-binding soluble 3 protein; lectin L-29; lectin, galactose binding, soluble 3; lectin, galactoside-binding, soluble, 3; LGALS3; MAC-2 antigen; unnamed protein product
Gene Aliases: AGE-R3; CBP30; CBP35; gal-3; GAL3; GALBP; GALIG; GBP; L-34; L31; LGALS2; Mac-2; MAC2
UniProt ID: (Human) P17931, (Rat) P08699
Entrez Gene ID: (Human) 3958, (Rat) 83781, (Mouse) 16854
RNA binding
protein phosphatase inhibitor activity
protein binding
IgE binding
protein phosphatase binding
carbohydrate binding
chemoattractant activity
laminin binding
disaccharide binding
oligosaccharide binding
molecular condensate scaffold activity
receptor ligand inhibitor activity
Fc-gamma receptor I complex binding
monosaccharide binding
advanced glycation end-product receptor activity
receptor inhibitor activity
monocyte chemotaxis
neutrophil chemotaxis
epithelial cell differentiation
positive regulation of protein complex assembly
killing of cells of other organism
regulation of T cell proliferation
negative regulation of endocytosis
eosinophil chemotaxis
macrophage chemotaxis
negative regulation of T cell receptor signaling pathway
positive chemotaxis
negative regulation of NK T cell activation
antimicrobial humoral immune response mediated by antimicrobial peptide
regulation of T cell apoptotic process
mononuclear cell migration
positive regulation of mononuclear cell migration
positive regulation of calcium ion import
regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of protein localization to plasma membrane
negative regulation of immunological synapse formation
negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
positive regulation of dendritic cell differentiation
negative regulation of extrinsic apoptotic signaling pathway
skeletal system development
positive regulation of cell proliferation
positive regulation of serotonin secretion
extracellular matrix organization
negative regulation of apoptotic process
maintenance of protein location
positive regulation of angiogenesis
negative regulation of cell proliferation in bone marrow
response to quercetin
NK T cell activation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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