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Proteintech
C9orf72 Monoclonal Antibody (3D2H6)
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Product Details
66140-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
3D2H6
Immunogen
C9orf72 Fusion Protein Ag21080 (1-222 aa encoded by BC020851)
Conjugate
Form
Liquid
Concentration
1.17 mg/mL
Amount
175.5 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSTLCPPPS PAVAKTEIAL SGKSPLLAAT FAYWDNILGP RVRHIWAPKT EQVLLSDGEI TFLANHTLNG EILRNAESGA IDVKFFVLSE KGVIIVSLIF DGNWNGDRST YGLSIILPQT ELSFYLPLHR VCVDRLTHII RKGRIWMHKE RQENVQKIIL EGTERMEDQG (1-222 aa encoded by BC020851)
Target Information
C9orf72 may play a role in endosomal trafficking and autophagy. It is known to interact with HNRNPA1, HNRNPA2B1, UBQLN2, and small Rab GTPSases. C9orf72 localizes in the nucleus, cytoplasm, endosome, lysosome, and autophagosome. Mutations in this gene can result in frontotemporal dementia and/or amyotrophic lateral sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: guanine nucleotide exchange C9orf72; Guanine nucleotide exchange factor C9orf72; Guanine nucleotide exchange factor C9orf72 homolog; protein C9orf72; protein C9orf72 homolog; unnamed protein product
Gene Aliases: AI840585; ALSFTD; C9orf72; DENND9; DENNL72; FTDALS; FTDALS1
UniProt ID: (Mouse) Q6DFW0, (Human) Q96LT7, (Rat) Q66HC3
Entrez Gene ID: (Mouse) 73205, (Human) 203228, (Rat) 313155
endocytosis
autophagy
negative regulation of protein phosphorylation
regulation of autophagy
positive regulation of macroautophagy
regulation of protein localization
stress granule assembly
negative regulation of exocytosis
axon extension
negative regulation of immune response
autophagosome-lysosome fusion
regulation of synaptic vesicle cycle
regulation of actin filament organization
late endosome to lysosome transport
regulation of TORC1 signaling
regulation of autophagosome assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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