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Proteintech
TPT1 Monoclonal Antibody (1G6A10)
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Product Details
66713-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1G6A10
Immunogen
TPT1 Fusion Protein Ag27651 (1-172 aa encoded by BC003352)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
150 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody detected 22 kDa TPT1 in lysates.
Immunogen sequence: MIIYRDLIS HDEMFSDIYK IREIADGLCL EVEGKMVSRT EGNIDDSLIG GNASAEGPEG EGTESTVITG VDIVMNHHLQ ETSFTKEAYK KYIKDYMKSI KGKLEEQRPE RVKPFMTGAA EQIKHILANF KNYQFFIGEN MNPDGMVALL DYREDGVTPY MIFFKDGLEM EKC (1-172 aa encoded by BC003352)
Target Information
TPT1 (translationally controlled tumor protein 1) is a 23 kDa member of the TCTP family of calcium binding proteins. TPT1 is localized in the cytoplasm and widely expressed and serves as a transcriptional activator, calcium transporter, histamine inducer and antiapoptotic caspase 3 inhibitor. TPT1 is a cytokine-like molecule that causes the release of histamine, IL-4 and IL-13 from basophils as well as the secretion of IL-8 and a calcium response in eosinophils. TPT1 plays a pivotal role in allergic diseases and due to its wide distribution in brain, is thought to be involved in neurodegenerative disorders, such as Alzheimer's disease and Down syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 21 kDa polypeptide; 21 kDa polypeptide under translational control; Fortilin; Histamine-releasing factor; HRF; Lens epithelial protein; p21; p23; TCTP; TPT1; translationally regulated transcript (21 kDa); Translationally-controlled tumor protein; unnamed protein product
Gene Aliases: HRF; p02; p21; p23; TCTP; TPT1; Trt
UniProt ID: (Human) P13693, (Mouse) P63028, (Rat) P63029
Entrez Gene ID: (Human) 7178, (Mouse) 22070, (Rat) 116646
calcium ion transport
cellular calcium ion homeostasis
response to virus
stem cell population maintenance
regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of ectoderm development
spermatogenesis
cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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