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Proteintech
PI3 Kinase p110 Beta Monoclonal Antibody (1B2A1)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
67121-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1B2A1
Immunogen
PIK3CB Fusion Protein Ag17505
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
860 µg/mL
Amount
129 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
PIK3CB (phosphatyidylinositol 4,5-biphosphate 3-kinase catalyic subunit beta isoform) is a phosphoinositide-3-kinase that phosphorylates PtdIns (phosphatidylinositol), PtdIns4P (phosphatidylinositol 4-phosphate), and PtdIns(4,5)P2 (phosphatidylinositol 4,5-biphosphate) to generate phosphatidylinositol 3,4,5-triphosphate (PIP3). PIP3 plays a key role in recruiting PH domain-containing proteins to the membrane and activating signaling cascades involved in cell growth, survival, proliferation, motility, and morphology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 110 kda catalytic subunit; catalytic phosphatidylinositol 3-kinase beta; p110beta; phosphatidylinositol 3-kinase, catalytic, beta polypeptide; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; phosphoinositide-3-kinase, catalytic, beta polypeptide; PI3-kinase p110 subunit beta; PI3-kinase subunit beta; PI3K; PI3K-beta; PI3Kbeta; pi3kcb; PtdIns-3-kinase p110; ptdIns-3-kinase subunit beta; ptdIns-3-kinase subunit p110-beta; serine/threonine protein kinase PIK3CB; unnamed protein product
Gene Aliases: P110BETA; PI3K; PI3KBETA; PIK3C1
UniProt ID: (Human) P42338, (Rat) Q9Z1L0
Entrez Gene ID: (Human) 5291, (Rat) 85243
endothelial cell proliferation
regulation of cell-matrix adhesion
response to ischemia
sphingosine-1-phosphate signaling pathway
cellular calcium ion homeostasis
homophilic cell adhesion via plasma membrane adhesion molecules
positive regulation of endothelial cell migration
positive regulation of gene expression
cell migration
platelet activation
positive regulation of neutrophil apoptotic process
positive regulation of Rac protein signal transduction
phosphatidylinositol-3-phosphate biosynthetic process
embryonic cleavage
natural killer cell mediated cytotoxicity
negative regulation of MAPK cascade
protein kinase B signaling
positive regulation of nitric oxide biosynthetic process
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
negative regulation of protein kinase B signaling
angiogenesis involved in wound healing
negative regulation of vascular endothelial growth factor signaling pathway
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
negative regulation of sprouting angiogenesis
leukocyte mediated immunity
chemotaxis
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
G-protein coupled receptor signaling pathway
positive regulation of autophagy
regulation of cell adhesion
innate immune response
platelet aggregation
regulation of clathrin-mediated endocytosis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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