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SERCA2/ATP2A2 Monoclonal Antibody (1F11A11)
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FIGURE: 1 / 5
SERCA2/ATP2A2 Antibody (67248-1-IG) in IHC (P)
Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue slide using (Product # 67248-1-IG) (SERCA2,ATP2A2 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
67248-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1F11A11
Immunogen
SERCA2,ATP2A2 Fusion Protein Ag5052
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1000 µg/mL
Amount
150 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATPase Ca++ transporting cardiac muscle slow twitch 2; ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2; ATPase, Ca++ transporting, cardiac muscle, slow twitch 2; ATPase, Ca++ transporting, slow twitch 2; calcium ATPase; calcium pump 2; cardiac Ca2+ ATPase; endoplasmic reticulum class 1/2 Ca(2+) ATPase; HK1; HK2; non-muscle ATPase; sarco(endo)plasmic reticulum Ca(2+)-dependent ATPase 2; sarco/endoplasmic reticulum Ca2+-ATPase 2; SERCA; SERCA ATPase; SERCA-2b class 2; SR Ca(2+)-ATPase 2; unnamed protein product
Gene Aliases: 9530097L16Rik; ATP2B; D5Wsu150e; DAR; DD; mKIAA4195; RHABDO2; SERCA2; Serca2a; SERCA2B; SercaII
UniProt ID: (Human) P16615, (Rat) P11507, (Mouse) O55143
Entrez Gene ID: (Human) 488, (Rat) 29693, (Mouse) 11938
nucleotide binding
calcium channel regulator activity
calcium-transporting ATPase activity
calcium ion binding
protein binding
ATP binding
ATPase activity
enzyme binding
ion channel binding
S100 protein binding
calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential
lncRNA binding
lutropin-choriogonadotropic hormone receptor binding
autophagosome assembly
muscle system process
calcium ion transport
cellular calcium ion homeostasis
regulation of muscle contraction
cell adhesion
epidermis development
positive regulation of heart rate
regulation of cardiac muscle contraction by calcium ion signaling
autophagosome membrane docking
endoplasmic reticulum calcium ion homeostasis
positive regulation of endoplasmic reticulum calcium ion concentration
ion transmembrane transport
response to endoplasmic reticulum stress
relaxation of cardiac muscle
sarcoplasmic reticulum calcium ion transport
calcium ion transmembrane transport
regulation of cardiac muscle cell membrane potential
regulation of cardiac muscle cell action potential involved in regulation of contraction
organelle localization by membrane tethering
calcium ion transport from cytosol to endoplasmic reticulum
regulation of cardiac conduction
calcium ion import into sarcoplasmic reticulum
regulation of the force of heart contraction
ER-nucleus signaling pathway
regulation of heart contraction
positive regulation of cardiac muscle cell apoptotic process
transition between fast and slow fiber
cardiac muscle hypertrophy in response to stress
response to lipopolysaccharide
T-tubule organization
cellular response to oxidative stress
cellular response to heat
negative regulation of heart contraction
relaxation of skeletal muscle
regulation of calcium ion-dependent exocytosis of neurotransmitter
response to peptide hormone
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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