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Proteintech

SERCA2/ATP2A2 Monoclonal Antibody (1F11A11)

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View all (19) SERCA2 ATPase antibodies

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Product Details

67248-1-IG

Applications
Tested Dilution
Publications

Western Blot (WB)

1:10,000
View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1F11A11

Immunogen

SERCA2,ATP2A2 Fusion Protein Ag5052

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1000 µg/mL

Amount

150 µg

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: ATPase Ca++ transporting cardiac muscle slow twitch 2; ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2; ATPase, Ca++ transporting, slow twitch 2; calcium ATPase; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; cardiac Ca2+ ATPase; Endoplasmic reticulum class 1/2 Ca(2+) ATPase; HK1; HK2; sarco(endo)plasmic reticulum Ca(2+)-dependent ATPase 2; sarco/endoplasmic reticulum Ca2+-ATPase 2; Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; SERCA; SERCA ATPase; SERCA2; SR Ca(2+)-ATPase 2; unnamed protein product

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Gene Aliases: 9530097L16Rik; ATP2A2; ATP2B; D5Wsu150e; DAR; DD; mKIAA4195; RHABDO2; SERCA2; Serca2a; SERCA2B; SercaII

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UniProt ID: (Human) P16615, (Mouse) O55143, (Rat) P11507

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Entrez Gene ID: (Human) 488, (Mouse) 11938, (Rat) 29693

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Function(s)
nucleotide binding calcium channel regulator activity calcium-transporting ATPase activity calcium ion binding protein binding ATP binding ATPase activity enzyme binding ion channel binding S100 protein binding metal ion binding calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential lncRNA binding protein C-terminus binding hydrolase activity lutropin-choriogonadotropic hormone receptor binding primary active transporter
Process(es)
autophagosome assembly regulation of the force of heart contraction muscle system process ion transport calcium ion transport cellular calcium ion homeostasis regulation of muscle contraction ER-nucleus signaling pathway cell adhesion epidermis development positive regulation of heart rate positive regulation of cardiac muscle cell apoptotic process regulation of cardiac muscle contraction by calcium ion signaling transition between fast and slow fiber cardiac muscle hypertrophy in response to stress autophagosome membrane docking endoplasmic reticulum calcium ion homeostasis positive regulation of endoplasmic reticulum calcium ion concentration T-tubule organization ion transmembrane transport cellular response to oxidative stress response to endoplasmic reticulum stress negative regulation of heart contraction relaxation of cardiac muscle neuron cellular homeostasis sarcoplasmic reticulum calcium ion transport calcium ion transmembrane transport regulation of cardiac muscle cell membrane potential regulation of cardiac muscle cell action potential involved in regulation of contraction organelle localization by membrane tethering regulation of calcium ion-dependent exocytosis of neurotransmitter calcium ion transport from cytosol to endoplasmic reticulum regulation of cardiac conduction calcium ion import into sarcoplasmic reticulum mitochondrion-ER tethering transport organelle organization response to peptide hormone metabolic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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