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Proteintech
TXNRD1 Monoclonal Antibody (1B10C4)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
67728-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1B10C4
Immunogen
TXNRD1 fusion protein Ag30071
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
294 µg/mL
Amount
44.1 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: gene associated with retinoic and IFN-induced mortality 12 protein; gene associated with retinoic and interferon-induced mortality 12 protein; KM-102-derived reductase-like factor; MGC9145; NADPH-dependent thioredoxin reductase; oxidoreductase; peroxidase TXNRD1; redox enzyme; selenoprotein oxidoreductase; selenoprotein TXNRD1; testis tissue sperm-binding protein Li 46a; thioredoxin reductase GRIM-12; thioredoxin reductase TR1; TR alpha; TR1; TXNRD1; unnamed protein product
Gene Aliases: GRIM-12; TR; TR1; TRXR1; TXNR; TXNR1
UniProt ID: (Human) Q16881, (Mouse) Q9JMH6
Entrez Gene ID: (Human) 7296, (Rat) 58819, (Mouse) 50493
thioredoxin-disulfide reductase activity
protein binding
oxidoreductase activity
oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
identical protein binding
NADPH peroxidase activity
flavin adenine dinucleotide binding
FAD binding
methylselenol reductase activity
methylseleninic acid reductase activity
NAD(P)H oxidase activity
selenate reductase activity
mercury ion binding
mesoderm formation
response to oxidative stress
gastrulation
cell proliferation
response to xenobiotic stimulus
response to selenium ion
benzene-containing compound metabolic process
hydrogen peroxide catabolic process
positive regulation of apoptotic process
cell redox homeostasis
response to axon injury
response to hyperoxia
halogen metabolic process
cellular response to copper ion
cellular response to hyperoxia
cellular oxidant detoxification
selenium compound metabolic process
signal transduction
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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