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          • Primary Antibodies ›
          • Noggin Antibodies

          Proteintech

          Noggin Monoclonal Antibody (2A11C1), NeutraKine®

          View all (28) Noggin antibodies

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          Cite Noggin Monoclonal Antibody (2A11C1), NeutraKine®

          Additional Information:
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          • Antibody Testing Data (3)
          Noggin Antibody in Flow Cytometry (Flow)
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          Noggin Antibody in Flow Cytometry (Flow)
          Group 53 Created with Sketch.

          FIGURE: 1 / 3

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          Noggin Antibody (69010-1-IG) in Flow

          1X10^6 PC-3 cells were stained with 0.5 µg NeutraKine® Noggin antibody (69010-1-Ig, Clone: 2A11C1) and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L) at dilution 1:1000 (green), or stained with 0.5 µg isotype control and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L) at dilution 1:1000 (black). Cells were fixed with 4% PFA and permeabilized with 0.1% Triton X-100. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          View Product

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          Noggin Antibody in Flow Cytometry (Flow)
          Noggin Antibody in ELISA (ELISA)
          Noggin Antibody in Neutralization (Neu)

          Product Details

          69010-1-IG

          Applications
          Tested Dilution
          Publications

          Flow Cytometry (Flow)

          0.5 µg
          -

          ELISA (ELISA)

          70 ng/well
          -

          Neutralization (Neu)

          40 ng/mL
          -
          Product Specifications

          Species Reactivity

          Human

          Host/Isotype

          Mouse / IgG1

          Class

          Monoclonal

          Type

          Antibody

          Clone

          2A11C1

          Immunogen

          NeutraKine Noggin fusion protein HZ-1118

          Conjugate

          Unconjugated Unconjugated Unconjugated
          • CoraLite Plus 488
          • CoraLite Plus 647
          • Request custom conjugation

          Form

          Lyophilized

          Purification

          Protein G

          Storage buffer

          PBS

          Contains

          no preservative

          Storage conditions

          Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

          Shipping conditions

          Wet ice

          Product Specific Information

          Reconstitute with water to the desired concentration.

          Lyophilized antibodies are stable for 1 year from the date of purchase if stored between -20 to -80°C. Upon reconstitution, we recommend that the solution be stored at 4°C (short- term) or at -20 to -80°Cfor long term. Repeated freeze-thaw cycles should be avoided with reconstituted products.

          Aliquoting is unnecessary for -20°C storage.

          Target Information

          Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor. Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Let us know so we can reference it here.
          Cite this product

          Bioinformatics

          Protein Aliases: Noggin; Noggin precursor; symphalangism 1 (proximal); unnamed protein product

          View more View less

          Gene Aliases: NOG; SYM1; SYNS1; SYNS1A

          View more View less

          UniProt ID: (Human) Q13253

          View more View less

          Entrez Gene ID: (Human) 9241

          View more View less

          Function(s)
          protein binding growth factor binding protein homodimerization activity receptor ligand inhibitor activity
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter skeletal system development osteoblast differentiation urogenital system development ureteric bud development in utero embryonic development endoderm formation mesoderm formation epithelial to mesenchymal transition neural plate morphogenesis neural tube closure membranous septum morphogenesis outflow tract morphogenesis ventricular compact myocardium morphogenesis endocardial cushion formation smoothened signaling pathway pattern specification process nervous system development axon guidance central nervous system development brain development endoderm development mesoderm development motor neuron axon guidance cell proliferation visual learning fibroblast growth factor receptor signaling pathway dorsal/ventral pattern formation positive regulation of gene expression negative regulation of gene expression spinal cord development cell differentiation in hindbrain neural tube development pituitary gland development neural plate anterior/posterior regionalization cell differentiation negative regulation of cell migration BMP signaling pathway regulation of BMP signaling pathway negative regulation of BMP signaling pathway forebrain development somatic stem cell population maintenance exploration behavior nodal signaling pathway regulation of fibroblast growth factor receptor signaling pathway wound healing middle ear morphogenesis embryonic digit morphogenesis negative regulation of cell differentiation negative regulation of osteoblast differentiation positive regulation of transcription from RNA polymerase II promoter regulation of neuronal synaptic plasticity axial mesoderm development embryonic organ morphogenesis notochord morphogenesis anatomical structure formation involved in morphogenesis embryonic skeletal system development negative regulation of astrocyte differentiation mesenchymal cell differentiation stem cell differentiation epithelial cell proliferation positive regulation of epithelial cell proliferation cartilage development atrial cardiac muscle tissue morphogenesis negative regulation of cardiac muscle cell proliferation limb development embryonic skeletal joint morphogenesis long-term synaptic potentiation face morphogenesis negative regulation of SMAD protein import into nucleus ventricular septum morphogenesis lung morphogenesis prostatic bud formation ureteric bud formation negative regulation of cartilage development somite development heart trabecula morphogenesis pharyngeal arch artery morphogenesis negative regulation of cardiac epithelial to mesenchymal transition cellular response to BMP stimulus negative regulation of canonical Wnt signaling pathway positive regulation of branching involved in ureteric bud morphogenesis positive regulation of glomerulus development presynaptic modulation of chemical synaptic transmission cranial skeletal system development short-term synaptic potentiation negative regulation of apoptotic signaling pathway
          It has to be done as per old AB suggested Products section.

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          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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