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Invitrogen

Phospho-LRRK2 (Ser935) Recombinant Rabbit Monoclonal Antibody (3H8L19)

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Phospho-LRRK2 (Ser935) Recombinant Rabbit Monoclonal Antibody (3H8L19)

Product Details

701066

Applications
Tested Dilution
Publications

Western Blot (WB)

2-5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1:10-1:50
-

Immunocytochemistry (ICC/IF)

1 µg/mL
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Product Specifications

Species Reactivity

Human

Published species

Rat

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

3H8L19

Immunogen

Phosphopeptide corresponding to amino acids 930-940 of human LRRK2
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2532367

Product Specific Information

This antibody is predicted to react with non-human primate, mouse and rat based on sequence homology.

Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Mutations in LRRK2 have been associated with Parkinson's disease. LRRK2 is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: augmented in rheumatoid arthritis 17; BC 300-268; Dardarin; DKFZp434H2111; FLJ45829; Leucine-rich repeat serine/threonine-protein kinase 2; LRR kinase 2; LRRK 2; LRRK-2

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Gene Aliases: AURA17; DARDARIN; LRRK2; PARK8; RIPK7; ROCO2

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UniProt ID: (Human) Q5S007

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Entrez Gene ID: (Human) 120892

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Function(s)
SNARE binding nucleotide binding magnesium ion binding actin binding GTPase activity protein kinase activity protein serine/threonine kinase activity JUN kinase kinase kinase activity MAP kinase kinase kinase activity GTPase activator activity protein binding ATP binding GTP binding microtubule binding tubulin binding kinase activity transferase activity hydrolase activity syntaxin-1 binding receptor signaling complex scaffold activity clathrin binding small GTPase binding GTP-dependent protein kinase activity peroxidase inhibitor activity co-receptor binding identical protein binding protein homodimerization activity ion channel binding protein kinase A binding protein serine kinase activity beta-catenin destruction complex binding
Process(es)
MAPK cascade protein phosphorylation protein import into nucleus endocytosis autophagy response to oxidative stress mitochondrion organization endoplasmic reticulum organization Golgi organization lysosome organization cell surface receptor signaling pathway JNK cascade Rho protein signal transduction spermatogenesis neuromuscular junction development protein localization determination of adult lifespan cellular response to starvation anatomical structure morphogenesis negative regulation of signal transduction regulation of gene expression regulation of autophagy positive regulation of autophagy negative regulation of protein processing negative regulation of neuron projection development regulation of neuron maturation vesicle-mediated transport negative regulation of macroautophagy calcium-mediated signaling striatum development olfactory bulb development tangential migration from the subventricular zone to the olfactory bulb cell differentiation regulation of proteolysis neuron differentiation regulation of cell projection organization positive regulation of protein ubiquitination regulation of protein stability positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of tumor necrosis factor production negative regulation of GTPase activity cellular response to oxidative stress cellular response to reactive oxygen species regulation of SNARE complex assembly intracellular signal transduction regulation of kidney size exploration behavior locomotory exploration behavior regulation of lysosomal lumen pH regulation of locomotion regulation of membrane potential positive regulation of programmed cell death positive regulation of MAPK cascade negative regulation of Notch signaling pathway GTP metabolic process protein autophosphorylation intracellular distribution of mitochondria animal organ development neuron projection morphogenesis modulation of synaptic transmission regulation of multicellular organismal process positive regulation of protein metabolic process mitochondrion localization regulation of mitochondrial depolarization regulation of synaptic transmission, glutamatergic canonical Wnt signaling pathway excitatory postsynaptic potential regulation of dopamine receptor signaling pathway positive regulation of dopamine receptor signaling pathway regulation of vesicle-mediated transport regulation of ER to Golgi vesicle-mediated transport regulation of canonical Wnt signaling pathway regulation of dendritic spine morphogenesis protein localization to mitochondrion protein localization to endoplasmic reticulum exit site cellular response to manganese ion regulation of mitochondrial fission positive regulation of canonical Wnt signaling pathway negative regulation of excitatory postsynaptic potential neuron projection arborization regulation of cAMP/PKA signal transduction regulation of synaptic vesicle endocytosis positive regulation of synaptic vesicle endocytosis positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of protein autoubiquitination regulation of intracellular signal transduction regulation of neuroblast proliferation regulation of synaptic vesicle transport negative regulation of late endosome to lysosome transport negative regulation of autophagosome assembly negative regulation of protein targeting to mitochondrion negative regulation of protein processing involved in protein targeting to mitochondrion cellular response to dopamine positive regulation of microglial cell activation cellular response to curcumin Wnt signalosome assembly regulation of retrograde transport, endosome to Golgi regulation of CAMKK-AMPK signaling cascade regulation of branching morphogenesis of a nerve regulation of synaptic vesicle exocytosis regulation of reactive oxygen species metabolic process
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