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Invitrogen

TP63 Recombinant Rabbit Monoclonal Antibody (10H7L17)

Advanced Verification
2 Published Figures
3 References

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TP63 Recombinant Rabbit Monoclonal Antibody (10H7L17)

Product Details

703809

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 1 publication 1 publication

Immunohistochemistry (PFA fixed) (IHC (PFA))

-
View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:100
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

10H7L17

Immunogen

Protein corresponding to human TP63 [aa360-aa500]
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2809251

Product Specific Information

This antibody is predicted to react with Monkey, Mouse, Rat, Bovine.

Target Information

TP63 (tumor protein 63) acts as a sequence-specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform-specific activity. Isoform 2 activates RIPK4 transcription. TP63 may be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. It is involved in Notch signaling by inducing JAG1 and JAG2. TP63 plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. TP63 is required for limb formation from the apical ectodermal ridge. It also activates transcription of the p21 promoter. Mutations affecting the gene can result in Acro-dermato-ungual-lacrimal-tooth syndrome, ankyloblepharon-ectodermal defects-cleft lip/palate, ectrodactyly ectodermal dysplasia, split-hand/foot malformation 4, limb-mammary syndrome, ectodermal dysplasia - Rapp-Hodgkin type, and orofacial cleft 8.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: amplified in squamous cell carcinoma; Chronic ulcerative stomatitis protein; CUSP; deltaNp63delta; fifth splice variant; related to p53 and p73; first splice variant; related to p53 and p73; fourth splice variant; related to p53 and p73; Keratinocyte transcription factor KET; p40; p51; p53-like; p63; p63a; p73L; second splice variant; related to p53 and p73; sixth splice variant; related to p53 and p73; third splice variant; related to p53 and p73; TP63; Transformation-related protein 63; Tumor protein 63; tumor protein p53-competing protein; Tumor protein p73-like; unnamed protein product

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Gene Aliases: AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; p40; p51; p53CP; P63; P73H; P73L; RHS; SHFM4; TP53CP; TP53L; TP63; TP73L

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UniProt ID: (Human) Q9H3D4

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Entrez Gene ID: (Human) 8626

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding p53 binding DNA binding chromatin binding damaged DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding protein domain specific binding identical protein binding sequence-specific DNA binding metal ion binding WW domain binding MDM2/MDM4 family protein binding promoter-specific chromatin binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter skeletal system development establishment of planar polarity morphogenesis of a polarized epithelium hair follicle development epithelial cell development chromatin remodeling regulation of transcription, DNA-templated transcription from RNA polymerase II promoter apoptotic process cellular response to DNA damage stimulus Notch signaling pathway spermatogenesis pattern specification process ectoderm and mesoderm interaction positive regulation of cell proliferation determination of adult lifespan epidermis development organ morphogenesis epidermal cell differentiation proximal/distal pattern formation epidermal cell division regulation of epidermal cell division positive regulation of keratinocyte proliferation keratinocyte differentiation embryonic limb morphogenesis prostate gland development epithelial cell differentiation polarized epithelial cell differentiation hair follicle morphogenesis negative regulation of intracellular estrogen receptor signaling pathway embryonic forelimb morphogenesis embryonic hindlimb morphogenesis post-anal tail morphogenesis odontogenesis of dentin-containing tooth intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of apoptotic process skin morphogenesis keratinocyte proliferation positive regulation of cell differentiation negative regulation of keratinocyte differentiation positive regulation of osteoblast differentiation positive regulation of Notch signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter sympathetic nervous system development anatomical structure formation involved in morphogenesis female genitalia morphogenesis stem cell differentiation protein tetramerization neuron apoptotic process cloacal septation prostatic bud formation squamous basal epithelial stem cell differentiation involved in prostate gland acinus development establishment of skin barrier stem cell proliferation cellular senescence skin epidermis development positive regulation of cell cycle G1/S phase transition positive regulation of somatic stem cell population maintenance cranial skeletal system development positive regulation of fibroblast apoptotic process negative regulation of mesoderm development positive regulation of stem cell proliferation negative regulation of cellular senescence positive regulation of apoptotic signaling pathway
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