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Antibodies Inc
KChIP2b K+ Channel Monoclonal Antibody (K60/73), FL490
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Product Details
75-004-FL490
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
K60/73
Immunogen
Fusion protein amino acids 1-252 (full length) of rat KChIP2b (accession number AAF81756) produced recombinantly in E. Coli.
Conjugate
Excitation/Emission Max
491/515 nm
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
KChIP2b is an isoform of the Kv Channel-Interacting Protein 2 (KChIP2), which is a regulatory subunit that interacts with voltage-gated potassium (Kv) channels. This isoform modulates the biophysical properties of Kv channels, including their inactivation kinetics and surface expression, thereby influencing cardiac and neuronal excitability. Dysregulation of KChIP2b can impact heart function and has been implicated in conditions such as cardiac arrhythmias.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A-type potassium channel modulatory protein 2; A-type potassium channel modulatory protein KCNIP2; Cardiac voltage-gated potassium channel modulatory subunit; KChIP; KChIP2; KCHIP2.2; KCNIP2-Ia; KCNIP2-Ia#IIab; KCNIP2-Ia#IIb; KCNIP2-Ib#IIab; KCNIP2-Ic#IIab; Kv channel interacting protein 2; Kv channel-interacting protein; Kv channel-interacting protein 2; neuronal calcium sensor-1 homolog; potassium channel auxiliary subunit KCHIP2; potassium channel interacting protein; KChIP2; Potassium channel-interacting protein 2; unnamed protein product
Gene Aliases: KCHIP2; KCNIP2
UniProt ID: (Human) Q9NS61, (Mouse) Q9JJ69, (Rat) Q9JM59
Entrez Gene ID: (Human) 30819, (Pig) 100037948, (Dog) 403598, (Mouse) 80906, (Rat) 56817
A-type (transient outward) potassium channel activity
potassium channel activity
calcium ion binding
protein binding
potassium channel regulator activity
identical protein binding
ion channel binding
macromolecular complex binding
metal ion binding
ER retention sequence binding
voltage-gated ion channel activity
protein N-terminus binding
action potential
detection of calcium ion
ion transport
potassium ion transport
muscle contraction
signal transduction
chemical synaptic transmission
regulation of heart contraction
regulation of signal transduction
ion transmembrane transport
clustering of voltage-gated potassium channels
regulation of membrane repolarization
potassium ion transmembrane transport
membrane repolarization
membrane repolarization during cardiac muscle cell action potential
regulation of potassium ion transmembrane transport
regulation of potassium ion export across plasma membrane
positive regulation of potassium ion export across plasma membrane
transport
regulation of ion transmembrane transport
potassium ion export
protein heterooligomerization
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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