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Antibodies Inc
GABA-A-R/Beta3 Monoclonal Antibody (N87/25), FL550
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Product Details
75-149-FL550
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N87/25
Immunogen
Fusion protein amino acids 370-433 of mouse GABA-A-R-Beta3 (accession number AAB60502) produced recombinantly in E. Coli.
Conjugate
Excitation/Emission Max
550/575 nm
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
Gamma-amino butyric acid (GAMA) is a strong inhibitor of neuron transmission and is found throughout the central nervous system. GABA is formed by the decarboxylation of glutamate, resulting in the formation of one of two distinct types; GABA-A or GABA-B.The binding of GABA to GABA-A receptors results in the increase transportation of chlorine ions into the neuron. This influx results in signal transmission repression. Studies have shown that if cell to cell signaling goes unchecked due to a lack of GABA, a system overload can resulting in blackouts, rapid body contractions, seizures and epilepsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cleft palate 1; GABA(A) receptor subunit beta-3; GABA-alpha receptor beta-2 subunit; GABAA receptor beta-3 subunit; GABAAR subunit beta-3; GABR B3; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA) A receptor, beta 3; gamma-aminobutyric acid (GABA-A) receptor, subunit beta 3; gamma-aminobutyric acid A receptor beta 3; Gamma-aminobutyric acid receptor beta 3; Gamma-aminobutyric acid receptor subunit beta-3; gamma-aminobutyric acid receptor, subunit beta 3; gamma-aminobutyric acid type A receptor beta3 subunit; gamma-aminobutyric acid type A receptor subunit beta 3; MGC9051; testis gamma-aminobutyric acid receptor subunit beta 3; unnamed protein product
Gene Aliases: A230092K12Rik; AW049585; beta3; Cp1; DEE43; ECA5; EIEE43; Gabrb-3; GABRB3
UniProt ID: (Human) P28472, (Mouse) P63080, (Rat) P63079
Entrez Gene ID: (Human) 2562, (Mouse) 14402, (Rat) 24922
transmembrane signaling receptor activity
GABA-A receptor activity
ion channel activity
extracellular ligand-gated ion channel activity
chloride channel activity
GABA-gated chloride ion channel activity
identical protein binding
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
AP-2 adaptor complex binding
protein binding
ligand-gated ion channel
ion transport
chloride transport
signal transduction
gamma-aminobutyric acid signaling pathway
chemical synaptic transmission
nervous system development
brain development
learning
memory
response to xenobiotic stimulus
reproductive behavior
cerebellum development
ion transmembrane transport
social behavior
exploration behavior
circadian sleep/wake cycle, REM sleep
neuron development
synaptic transmission, GABAergic
palate development
hard palate development
inhibitory postsynaptic potential
inner ear receptor cell development
innervation
motor behavior
cellular response to zinc ion
cellular response to histamine
response to anesthetic
cochlea development
chloride transmembrane transport
inhibitory synapse assembly
transport
sensory perception of sound
regulation of neuron apoptotic process
negative regulation of neuron apoptotic process
negative regulation of neuron death
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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