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Invitrogen

HLA-G Monoclonal Antibody (MEM-G/9), APC

1 Published Figure
1 Reference
View all (56) HLA-G antibodies

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Product Details

A15708

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

1-5 µg/mL
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Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

MEM-G/9

Immunogen

Recombinant human HLA-G refolded with beta2-microglobulin and peptide.

Conjugate

APC APC APC

Excitation/Emission Max

651/660 nm View spectra spectra

Form

Liquid

Concentration

0.1 mg/mL

Amount

100 µg

Purification

Size-exclusion chromatography

Storage buffer

PBS, pH 7.4, with 0.2% BSA

Contains

15mM sodium azide

Storage conditions

4°C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2534488

Product Specific Information

This antibody reacts with an extracellular epitope on native form of human HLA-G1 on the cell surface as well as with soluble HLA-G5 isoform in its beta2-microglobulin associated form. Reactivity with HLA-G3 was also reported. The antibody MEM-G/9 is standard reagent thoroughly validated during 3rd International Conference on HLA-G (Paris, 2003).

Target Information

HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

How to use the Panel Builder

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Bioinformatics

Protein Aliases: b2 microglobulin; DADB-15K14.8; HLA class I histocompatibility antigen, alpha chain G; HLA G antigen; HLA-G; HLA-G histocompatibility antigen, class I, G; HOSA-G1; MHC class I antigen G; MHC class I protein; MHC class Ib antigen; mutant MHC class I antigen; mutant MHC class Ib antigen; unnamed protein product

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Gene Aliases: HLA-6.0; HLA-G; HLAG; MHC-G

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UniProt ID: (Human) P17693

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Entrez Gene ID: (Human) 3135

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Function(s)
receptor binding protein binding peptide antigen binding CD8 receptor binding identical protein binding protein homodimerization activity
Process(es)
negative regulation of T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity immune system process peripheral B cell tolerance induction antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of endogenous peptide antigen via MHC class Ib antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent positive regulation of tolerance induction positive regulation of T cell tolerance induction positive regulation of natural killer cell cytokine production immune response-inhibiting cell surface receptor signaling pathway immune response cellular defense response negative regulation of angiogenesis positive regulation of interleukin-12 production negative regulation of T cell proliferation protection from natural killer cell mediated cytotoxicity positive regulation of regulatory T cell differentiation negative regulation of natural killer cell mediated cytotoxicity negative regulation of immune response negative regulation of protein kinase B signaling positive regulation of macrophage cytokine production protein homotrimerization negative regulation of G0 to G1 transition positive regulation of endothelial cell apoptotic process positive regulation of cellular senescence negative regulation of dendritic cell differentiation
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